CBAC Cardiac Bioelectricity and Arrhythmia Center Research Goals  
 
 
 
     

Research Goals


Research projects at CBAC cover the entire spectrum from molecular and cellular processes to mechanisms, diagnosis and treatment of arrhythmias in patients. The cross-disciplinary structure of CBAC promotes collaborations between researchers and clinicians and fosters a multiple-approach strategy to the study, diagnosis and treatment of cardiac arrhythmias. Approaches include molecular, single-cell and whole-animal experiments, mathematical modeling and computer simulations, and patient studies during imaging, catheterization and open-heart surgery. Among the state-of-the-art techniques employed are genetics, biomolecular structural analysis, patch clamp recordings from single ion channels, ion-selective electrode measurements, high resolution electrical mapping, optical mapping of cardiac activation and cell-calcium, supercomputing and computer graphics, signal processing and image analysis.

Projects include:

  • Molecular structure and electrophysiological function of cardiac ion channels
  • Development of mathematical models of cardiac ion channels, cells and tissues
  • Regulatory pathways in cardiac cells
  • Mechanisms of hereditary cardiac arrhythmias
  • Arrhythmias in myocardial ischemia and infarction
  • Cell-to-cell communication and action potential propagation in the diseased heart
  • Ion-channel structure-function based drug design
  • Mechanisms of cardiac (ventricular and atrial) tachyarrhythmias and fibrillation
  • Development and application o f a novel imaging modality for cardiac arrhythmias
  • Mechanisms of cardiac resynchronization therapy for heart failure


 
     
   
 
Copyright ©2005-2017 CBAC. All rights reserved.
Contact Webmaster