CBAC Research  
 
 
 
     

Research Areas

Research projects at CBAC cover the entire spectrum from molecular and cellular processes to mechanisms, diagnosis and treatment of arrhythmias in patients. The cross-disciplinary structure of CBAC promotes collaborations between researchers and clinicians and fosters a multiple-approach strategy to the study, diagnosis and treatment of cardiac arrhythmias. Approaches include molecular, single-cell and whole-animal experiments, mathematical modeling and computer simulations, and patient studies during imaging, catheterization and open-heart surgery. Among the state-of-the-art techniques employed are genetics, biomolecular structural analysis, patch clamp recordings from single ion channels, ion-selective electrode measurements, high resolution electrical mapping, optical mapping of cardiac activation and cell-calcium, supercomputing and computer graphics, signal processing and image analysis.

Yoram RudyCBAC Director - Yoram Rudy, Ph.D., F.A.H.A., F.H.R.S.
The Fred Saigh Distinguished Professor of Engineering;
Professor of Biomedical Engineering, Cell Biology & Physiology, Medicine, Radiology, & Pediatrics

 

Research Interests:
• Cardiac Bioelectricity
• Cardiac Electrophysiology and Arrhythmias
• Computational Biology and Mathematical modeling
• Cardiac Imaging and Mapping

Websites:
rudylab.wustl.edu

cbac.wustl.edu

Email:
rudy@wustl.edu

R. Martin Arthur R. Martin Arthur, Ph.D.
Newton R. and Sarah Louisa Glasgow Wilson Emeritus Professor of Engineering; Emeritus Professor, the Preston M. Green Department of Electrical & Systems Engineering

 


Research Interests:
• Ultrasonic Imaging 
• Electrocardiography
• Signal & Image Processing


Website:
ee.wustl.edu


Email:

rma@wustl.edu

C. William (Bill) BalkeC. William (Bill) Balke, M.D.
Professor of Medicine, Cardiovascular Division
Chief of Cardiology,
St. Louis Veterans Affairs Medical Center (VAMC) & Health Care System

 


Research Interests:
Role of individual ions (especially calcium) as second messengers in the regulation of a variety of cellular
processes relevant to cardiovascular function


Website:

profiles.wustl.edu/en/persons/bill-balke

Email:
bill.balke@wustl.edu

Philip BaylyPhilip V. Bayly, Ph.D.
Department Chair & Professor, Lilyan & E. Lisle Hughes Prof. of Mechanical Engineering, Materials Science, & Biomedical Engineering



Research Interests:
• Biomechanics of Brain Development
• Dynamic Brain Deformation and Traumatic Brain Injury
• Mechanics of Cilia and Flagella


Website:
engineering.wustl.edu

Email:
pvb@wustl.edu

Sanjeev BhallaSanjeev Bhalla, M.D.
Chief of Cardiothoracic Imaging Services,Professor of Radiology; Assistant Director, Radiology Residence Program, Mallinckrodt Institute of Radiology




Research Interests:

• Chest Radiology
• Body Computed Tomography
• Emergency Radiology
• Cardiac Imaging
• Radiology

Website:
profiles.wustl.edu/en/persons/sanjeev-bhalla

Email:
sanjeevbhalla@wustl.edu

Daniel CooperDaniel H. Cooper, M.D.
Associate Prof. of Medicine, Cardiovascular Division; Director, Electrophysiology Fellowship Program

 

 

 


Research Interests:

Clinical and research interests revolve around the prevention of sudden cardiac death (SCD) and the understanding of the mechanisms that lead to ventricular arrhythmias and cardiac arrest.

Website:
profiles.wustl.edu/en/persons/daniel-cooper

Email:
cooperdh@wustl.edu

Phillip S. CuculichPhillip S. Cuculich, M.D.
Associate Professor of Medicine
Cardiovascular Division




 


Research Interests:
• Electrocardiographic Imaging (ECGI)
• HYBRID-AF Procedure
• Risks and Benefits of Implantable Defibrillators (ICDs)
• Cardiogenetic Syndromes

Clinical Interests:
Arrhythmias, inherited/genetic syndromes of the heart, sudden cardiac death, atrial fibrillation, ventricular tachycardia, electrophysiology, cardiovascular disease.

Website:
profiles.wustl.edu/en/persons/phillip-cuculich

Email:
pcuculic@wustl.edu

Jianmin CuiJianmin Cui, Ph.D.
Professor of Biomedical Engineering, Department of Biomedical Engineering

 


 



Research Interests:
•  Molecular mechanisms of ion channel activation
•  Ion Channels in Physiology and Disease
•  Discovery of channel-modifying compounds

 




Website:
research.engineering.wustl.edu

Email:
jcui@wustl.edu

Aart Dalal, D.O.Aarti Dalal, D.O.
Assistant Professor of Pediatrics, Cardiology

 



 

 

Clinical Interests:
Pediatric heart rhythm disorders, electrophysiology studies, catheter ablation and pacemaker/defibrillator implantation

 

 

 

 

 

 

Website:
profiles.wustl.edu/en/persons/aarti-dalal

Email:
asdalal@wustl.edu

Ralph J. DamianoRalph J. Damiano, Jr., M.D.
Evarts A. Graham
Professor of Surgery
Chief, Cardiothoracic Surgery

 




Research Interests:
Surgical treatment of arrhythmias; Pathophysiology of surgical ischemia; Hyperpolarizing cardioplegia; Cell volume regulation during cardioplegia; Transplant preservation (donor heart); Surgical robotics; Minimally invasive cardiac surgery

Clinical Interests:
Cardiac surgery, arrhythmia surgery,  off-pump cardiac surgery, coronary artery bypass graft (CABG) surgery, endoscopic CABG, beating heart surgery,  coronary artery revascularization, valve repair and replacement, minimally invasive cardiac surgery, myocardial preservation, surgical electrophysiology, transmyocardial laser revascularization,  TMR, HCM and robotic-assisted cardiac surgery.

Website:
profiles.wustl.edu/en/persons/ralph-damiano

Email:
damianor@wustl.edu

Victor Davila RomanVictor G. Davila-Roman, M.D., F.A.C.C. F.A.S.E.
Professor of Medicine,
Anesthesiology, Radiology
Medical Director, Cardiovascular Imaging & Clinical Research Core Laboratory

 

Clinical Interests:
Cardiomyopathy, magnetic resonance imaging, myocardiology, hypertension, vascular surgery, coronary artery disease, supervising and interpreting diagnostic tests, such as echocardiograms, stress echocardiograms, treadmill stress test, Holter, Event and Loop monitors

Website:
profiles.wustl.edu/en/persons/victor-davila-roman

Email:
vdavila@wustl.edu

Mitchell FaddisMitchell N. Faddis, M.D., Ph.D.
Professor of Medicine; Cardiovascular Division;
Director of Electrophysiology



 


Research Interests:
• Catheter ablation,
•  magnetic guidance,
•  congestive heart failure,
•  atrial fibrillation,
•  arrhythmia

Website:
profiles.wustl.edu/en/persons/mitch-faddis

Email:
faddism@wustl.edu

Michael GreenbergMichael J. Greenberg, Ph.D.
Assistant Professor of Biochemistry & Molecular Biophysics


 

 


Research Interests:
Understanding the regulation of cardiac power output in both health and disease

Website:
glab.biochem.wustl.edu/ (Lab)
profiles.wustl.edu/en/persons/michael-greenberg (Profile)

Email:
greenberg@wustl.edu

Richard GrossRichard W. Gross, M.D., Ph.D.
Professor of Medicine, Chemistry,& Developmental Biology; Division Chief, Bioorganic Chemistry & Molecular Pharmacology


 


Research Interests:
Chemical biology of membranes in health and disease


Website:
profiles.wustl.edu/en/persons/richard-grosschemistry.wustl.edu/people/richard-w-gross

Email:
rgross@wustl.edu

Nathaniel HuebschNathaniel Huebsch, Ph.D.
Assistant Professor
Department of Biomedical Engineering



 

 

 


Research Interests:
Professor Huebsch's research focus is in basic and translational stem cell mechanobiology, with specific focus on hydrogels to control cell-mediated tissue repair, and 3-D heart-on-a-chip models derived from human induced pluripotent stem cells.

Website:
engineering.wustl.edu/Profiles/Pages/Nathaniel-Huebsch.aspx

Email:
nhuebsch@wustl.edu

Gilbert JostR. Gilbert Jost, M.D.
Professor Emeritus of Radiology



 

 


 

Research Interests:
Radiology, medical imaging, new technologies, digital radiology, digital networking, x-rays, alternative screening

 


Website:

wuphysicians.wustl.edu

Email:
jostg@wustl.edu

Sandor KovacsSándor J Kovács, M.D., Ph.D.
Professor of Medicine & Physiology; Adj. Prof. of Physics & Biomedical Engineering; Director & Founder, Cardiovascular Biophysics Laboratory



Research Interests:
• Theoretical (mathematical) biology and physiology.
• Characterization of physical properties of cardiovascular tissue
• Maximal information extraction from in-vivo physiologic signals
• Mathematical modeling of cardiovascular function
• Nonlinear dynamics, thermodynamics and optimization principles of cardiovascular unction
• Development of new technology for imaging and physiologic signal acquisition and processing

Websites:
cbl1.wustl.edu (Lab)
profiles.wustl.edu/en/persons/sandor-kovacs (Profile)

Email:
sjk@wustl.edu

Douglas L. MannDouglas L. Mann, M.D.
Tobias & Hortense Lewin Professor,
Cardiovascular Division,
Wash. University School of Medicine


 



Research Interests:

The molecular and cellular basis of heart failure, with a particular emphasis on the role of inflammatory mediators in disease progression in the failing heart.

Clinical Interests:
Management of heart failure, transplant





Website:
profiles.wustl.edu/en/persons/douglas-mann


Email:

dmann@wustl.edu

Arye NehoraiArye Nehorai, Ph.D.
Eugene and Martha Lohman Professor, Preston M. Green Department of Electrical & Systems Engineering




 

 


Research Interests:

Statistical signal processing and imaging for security, defense, biomedicine, energy and the environment.

 

Website:
ese.wustl.edu


Email:

nehorai@wustl.edu

Jeanne NerbonneJeanne M. Nerbonne, Ph.D., F.A.H.A.
Alumni Endowed Professor of Molecular Biology & Pharmacology; Director, Center for Cardiovascular Research; Co-Director, CIMED; Depts. of Developmental Biology & Internal Medicine

 



Research Interests:
Defining the molecular mechanisms controlling the properties, the cell surface expression, and the functioning of voltage-gated K+ (Kv) channels in the cardiovascular and nervous systems.

Website:
nerbonnelab.wustl.edu
(Lab)
profiles.wustl.edu/en/persons/jeanne-nerbonne (Profile)

Email:
jnerbonne@wustl.edu

Colin NicholsColin G. Nichols, Ph.D.
Carl Cori Professor
Department of Cell Biology and Physiology
Director, Center for the Investigation of Membrane Excitability Diseases (CIMED)
Washington University School of Medicine

 

Research Interests:
The molecular and cellular regulation of ion channels, and their role in linking cellular metabolism to electrical activity in various tissues.

Website:
nicholslab.wustl.edu (Lab)
profiles.wustl.edu/en/persons/colin-nichols (Profile)


Email:
cnichols@wustl.edu

Joseph a o sullivanJoseph A. O’Sullivan, Ph.D.
Samuel C. Sachs Prof. of Electrical Engineering Professor
Professor & Dean of the UMSL/WUSTL Joint Undergraduate Engineering Program



Research Interests:
Information theory, estimation theory, and imaging science, with applications in object recognition, tomographic imaging, magnetic recording, radar, and formal languages.

Website:
essrl.wustl.edu



Email:

jao@wustl.edu

Maria RemediMaria S. Remedi, Ph.D.
Assistant Professor, Department of Medicine
Division of Endocrinology, Metabolism & Lipid Research,
Department of Cell Biology & Physiology




Research Interests:
• Study in vivo physiology in various mouse models of diabetes to unravel the underlying mechanisms of pancreatic β-cell failure in glucotoxic stages, and their consequences in both pancreatic and extra-pancreatic tissues


Website:
endo.wustl.edu/remedi-lab/ (Lab)
profiles.wustl.edu/en/persons/maria-remedi (Profile)

Email:
mremedi@wustl.edu

Stacey RentschlerStacey L. Rentschler, M.D., Ph.D.
Associate Professor of Medicine & Developmental Biology, Cardiovascular Division

 




Research Interests:
• Developmental Programming and Reprogramming of Conduction Tissue
• Molecular Basis of Congenital Heart Defects

 


Website:
rentschlerlab.wustl.edu (Lab)
profiles.wustl.edu/en/persons/stacey-rentschler (Profile)

Email:
stacey.rentschler@wustl.edu

Clifford RobinsonClifford G. Robinson, M.D.
Associate Professor
Radiation Oncology
Chief of Service, Stereotactic Body Radiation Therapy (SBRT); Director, Clinical Trials & Clinical Informatics

 



Research Interests:

• Optimizing dosing and delivery of radiotherapy with or without the addition of biologic modifiers for purposes of tumor control and normal tissue protection. See (.pdf) for more info.

Clinical Interests:
• Lung cancer, esophageal cancer, brain tumor, spine tumor, gamma knife, stereotactic body radiation therapy

Website:
profiles.wustl.edu/en/persons/clifford-robinson


Email:

clifford.robinson@wustl.edu

Rajan SahRajan Sah, M.D., Ph.D.
Associate Professor of Medicine
Cardiovascular Division


 


 


Research Interests:

• Ion channel signaling in the adipocyte
• Ion channel regulation of pancreatic β-cell function
• Modulators of calcium signaling in skeletal muscle
• Novel ion channel signaling in myocardium
• Ion channel signaling in endothelium



Website:

profiles.wustl.edu/en/persons/rajan-sah


Email:

rajan.sah@wustl.edu

Richard SchuesslerRichard B. Schuessler, Ph.D.
Director, Cardiothoracic Surgery Research Laboratory
Research Professor of Surgery (Cardiothoracic Surgery)
& Biomedical Engineering
Washington University School of Medicine

 

Research Interests:
• Surgical treatment of atrial fibrillation;
•  Mechanisms of atrial fibrillation;
•  Inflammatory mechanisms in postoperative atrial fibrillation; • Basic cardiac electrophysiology;
•  Normal and abnormal sinus node electrophysiology;
•  Mapping of cardiac electrophysiology;
•  Animal models of cardiac arrhythmias.


Website:
profiles.wustl.edu/en/persons/richard-schuessler

Email:
schuesslerr@wustl.edu

Jingyi ShiJingyi Shi, Ph.D.
Research Assistant Professor
Department of Biomedical Engineering



 



Research Interests:

• Molecular mechanisms of ion channel activation
• Ion channels in association with diseases
• Discovery of channel-modifying compounds

 




Website:
research.engineering.wustl.edu

Email:
jshi22@wustl.edu

Jennifer SilvaJennifer N. A. Silva, M.D.
Associate Professor of Pediatrics; Director of Pediatric Electrophysiology
Division of Pediatric Cardiology






Research Interests:
• 
Clinical Applications of Noninvasive Electrocardiographic Imaging (ECGI)
•  Pediatric Cardiac Resynchronization Therapy

Clinical Interests:
• 
Clinical Electrophysiology/Arrhythmias
•  Inherited Channelopathies
•  Transcatheter ablations
•  Pacemakers/Defibrillators
•  Heart Failure and Cardiac Resynchronization Therapy
•  Sudden Cardiac Death

Website:
profiles.wustl.edu/en/persons/jennifer-silva

Email:
jennifersilva@wustl.edu

Jon SilvaJonathan R. Silva, Ph.D.
Associate Professor
Department of Biomedical Engineering




 


Research Interests:
• Linking Changes in Molecular Conformation to Cardiac Function
• Spectroscopic Monitoring of Ion Channel Conformation
• Cardiac Ion Channel and Action Potential Modeling

 




Website:
silvalab.bme.wustl.edu

Email:
jonsilva@wustl.edu

Gautam SinghGautam K. Singh, M.D.
Professor of Pediatrics, Division of Pediatric Cardiology


 


 

Research Interests:
• Fetal cardiology
• Cardiac mechanics
• Strain imaging
• Cardiac MRI

 

Clinical Interests:
• Fetal cardiology,
• Preventive cardiology
• Hyperlipidemia
• Obesity in children
• Cardiac MRI

 

 

 

 


 

Website:
profiles.wustl.edu/en/persons/gautam-singh

Email:
singh_g@wustl.edu

Timothy W. SmithTimothy W. Smith, D.Phil., M.D., F.A.C.C., F.H.R.S.
Professor of Medicine, Cardiovascular Division, Washington University School of Medicine
Clinical Cardiac Electrophysiologist,
Barnes-Jewish Hospital

 


Research Interests:
• Cardiac cellular and tissue electrophysiology and mechanism of arrhythmias;
• Treatment of arrhythmias, including pharmacologic therapy, ablation therapy, and implantable device therapy;
• Device implantation techniques;
• Prevention of sudden cardiac death.

Clinical Interests:
• Cardiac Electrophysiology
• Bradyarrhythmias, including pacemaker implantation and management
• Supraventricular tachyarrhythmias, evaluation and management, including catheter procedures for diagnosis (electrophysiology study) and therapy (ablation). 
• Ventricular tachyarrhythmias and sudden cardiac death, including risk stratification, pharmacologic therapy.
• Implantable Defibrillator (ICD) implantation and management.
• Catheter procedures for diagnosis (electrophysiology study) and therapy (ablation).
• Atrial fibrillation, evaluation and management, including both pharmacologic and nonpharmacologic therapy.
• Cardiac Resynchronization for congestive heart failure. 
Implantation and management of cardiac resynchronization pacemakers/defibrillators

Website:
profiles.wustl.edu/en/persons/timothy-smith

Email:
tsmith@wustl.edu

Phyllis K. Stein, Ph.D., SEP Phyllis K. Stein, Ph.D., SEP
Associate Professor of Medicine
Director, Washington University School of Medicine HRV Lab


 



Research Interests:

Her work as the PI of the Washington University School of Medicine HRV (Heart Rate Variability) Laboratory has focused on using continuous ECG signals from Holter monitors, sleep studies, NICU and PICU signals and physiology labs to measure cardiac autonomic functioning. Her lab is one of the leading research HRV facilities in the world and they have developed sophisticated algorithms for examining heart rate patterns that go way beyond standard clinical measures.  They are experts in identifying and quantifying heart rate patterns that provide previously-unappreciated markers for healthy and unhealthy autonomic functioning in adults, children, babies and in genetically modified mice.  Her lab has data on about 20,000 subjects.

Her lab also offers training in HRV analytic techniques.  Her lab is currently creating an organized archive of studies and the signals, ECG-derived analyses, and projects or publications resulting from them.  The archive will also contain all of the HRV analyses that can be applied to each dataset. They have also published on ECG-waveform-based analyses, including QTVI and modified moving average T-wave alternans. 


Websites:

hrvlab.wustl.edu (Lab)
profiles.wustl.edu/en/persons/phyllis-stein (Profile)

Email:
pstein@wustl.edu

Jason TrobaughJason W. Trobaugh, D.Sc.
Professor of Practice
Department of Electrical & Systems Engineering






Research Interests:
• Probabilistic models for ultrasound images
• Model-based image analysis
• Treatment guidance applications for ultrasonic imaging
• Clinical applications of inverse electrocardiography
• Ultrasonic temperature imaging for management of thermal therapies

 

 

 

 

 

 

 

 




Website:
ese.wustl.edu

Email:
jasont@wustl.edu

George Van HareGeorge F. Van Hare, M.D.
The Louis Larrick Ward Professor of Pediatrics
Co-director, St Louis Children’s & Washington University Heart Center




Research Interests:
• Multicenter clinical research in pediatric heart rhythm disorders; • Biology of atrioventricular node reentry;
• Mapping and ablation of post-operative atrial and ventricular tachycardia

Clinical Interests:
• Heart rhythm disorders in children, and in adults with congenital heart disease;
• Radiofrequency catheter ablation, cryoablation, pacemaker, implantable cardioverter-defibrillator, (ICD), implantation and follow-up.

Website:
profiles.wustl.edu/en/persons/george-van-hare


Email:

vanhareg@wustl.edu

Pamela WoodardPamela K. Woodard, M.D., F.A.C.R., F.A.H.A., F.C.C.P.
Director, Center for Clinical Imaging Research (CCIR); Wilson Professor of Radiology & Biomedical Engineering; Head, Adv. Cardiac Imaging (CT/MRI);

 


Research Interests:
• Assessment of MRI techniques for the diagnosis of pulmonary  thromboembolism and builds on the work of PIOPED II (assessment of multidetector spiral CT for PE detection)
• Assessment, characterization and prediction of stabiliy of atherosclerotic plaque
• Coronary CT Angiography 

Clinical Interests:
Cardiac CT and MRI, pulmonary embolism diagnosis


Websites:

ccir.wustl.edu
(Lab)
profiles.wustl.edu/en/persons/pamela-woodard (Profile)

Email:
woodardp@wustl.edu

Chao ZhouChao Zhou, PhD
Associate Professor
Department of Biomedical Engineering

 

 



 

Research Interests:
• Space-division multiplexing optical coherence tomography (SDM-OCT)
• Molecular-targeted OCT and OCM for cancer detection
• OCT and OCM Imaging in Developmental Biology
• 3D OCT imaging of Brain Functions
• OCT (OCM) combined with deep learning
• Optogenetic pacing in Drosophila melanogaster using integrated OCM imaging and red light stimulation system



Websites:

zlab.wustl.edu


Email:

chaozhou@wustl.edu

 

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