CBAC Research  
 
 
 
     

Research Areas

Research projects at CBAC cover the entire spectrum from molecular and cellular processes to mechanisms, diagnosis and treatment of arrhythmias in patients. The cross-disciplinary structure of CBAC promotes collaborations between researchers and clinicians and fosters a multiple-approach strategy to the study, diagnosis and treatment of cardiac arrhythmias. Approaches include molecular, single-cell and whole-animal experiments, mathematical modeling and computer simulations, and patient studies during imaging, catheterization and open-heart surgery. Among the state-of-the-art techniques employed are genetics, biomolecular structural analysis, patch clamp recordings from single ion channels, ion-selective electrode measurements, high resolution electrical mapping, optical mapping of cardiac activation and cell-calcium, supercomputing and computer graphics, signal processing and image analysis.

Yoram RudyCBAC Director - Yoram Rudy, Ph.D., F.A.H.A., F.H.R.S.
The Fred Saigh Distinguished Professor of Engineering;
Professor of Biomedical Engineering, Cell Biology & Physiology, Medicine, Radiology, & Pediatrics



Research Interests:

• Cardiac Bioelectricity
• Cardiac Electrophysiology and Arrhythmias
• Computational Biology and Mathematical modeling
• Cardiac Imaging and Mapping

Websites:
rudylab.wustl.edu

cbac.wustl.edu

Email:
rudy@wustl.edu

R. Martin Arthur R. Martin Arthur, Ph.D.
Newton R. and Sarah Louisa Glasgow Wilson Professor of Engineering; Professor & Interim Chair of the Preston M. Green Department of Electrical & Systems Engineering; Professor of Biomedical Engineering

Research Interests:
• Ultrasonic Imaging 
• Electrocardiography
• Signal & Image Processing

 

 

Website:
ee.wustl.edu

Email:
rma@wustl.edu

C. William (Bill) BalkeC. William (Bill) Balke, M.D.
Professor of Medicine, Cardiovascular Division
Chief of Cardiology,
St. Louis Veterans Affairs Medical Center (VAMC) & Health Care System



 

Research Interests:
Role of individual ions (especially calcium) as second messengers in the regulation of a variety of cellular
processes relevant to cardiovascular function

Website:
cardiovascularresearch.wustl.edu/labs/c-william-balke-md/

Email:
bill.balke@wustl.edu

Philip BaylyPhilip V. Bayly, Ph.D.
Department Chair and Professor, Lilyan and E. Lisle Hughes Professor of Mechanical Engineering and Materials Science, and Biomedical Engineering



Research Interests:

• Biomechanics of Brain Development
• Dynamic Brain Deformation and Traumatic Brain Injury
• Mechanics of Cilia and Flagella

 

Website:
engineering.wustl.edu/~baylyp

Email:
pvb@wustl.edu

Sanjeev BhallaSanjeev Bhalla, M.D.
Chief of Cardiothoracic Imaging Services, Associate Professor of Radiology; Assistant-Director, Radiology Residence Program, Mallinckrodt Institute of Radiology



Research Interests:
• Chest Radiology
• Body Computed Tomography
• Emergency Radiology
• Cardiac Imaging
• Radiology

Website:
wuphysicians.wustl.edu

Email:
sanjeevbhalla@wustl.edu

Daniel CooperDaniel H. Cooper, M.D.
Assistant Professor of Medicine, Cardiovascular Division; Director, Electrophysiology Fellowship Washington University School of Medicine




Research Interests:
Clinical and research interests revolve around the prevention of sudden cardiac death (SCD) and the understanding of the mechanisms that lead to ventricular arrhythmias and cardiac arrest.

Website:
cardiology.wustl.edu

Email:
dcooper@wustl.edu

Phillip S. CuculichPhillip S. Cuculich, M.D.
Associate Professor of Medicine
Cardiovascular Division
Washington University School of Medicine





Research Interests:
• Electrocardiographic Imaging (ECGI)
• HYBRID-AF Procedure
• Risks and Benefits of Implantable Defibrillators (ICDs)
• Cardiogenetic Syndromes

Clinical Interests:
Arrhythmias, inherited/genetic syndromes of the heart, sudden cardiac death, atrial fibrillation, ventricular tachycardia, electrophysiology, cardiovascular disease.

Website:
cardiology.wustl.edu

Email:
pcuculic@wustl.edu

Jianmin CuiJianmin Cui, Ph.D.
Spencer T. Olin Distinguished Professor of Biomedical Engineering

 

 

 


Research Interests:

•  Molecular mechanisms of ion channel activation
•  Ion Channels in Physiology and Disease
•  Discovery of channel-modifying compounds

 



 

Website:
research.engineering.wustl.edu

Email:
jcui@wustl.edu

Ralph J. DamianoRalph J. Damiano, Jr., M.D.
Evarts A. Graham
Professor of Surgery
Chief, Cardiothoracic Surgery Washington University School of Medicine




Research Interests:
Surgical treatment of arrhythmias; Pathophysiology of surgical ischemia; Hyperpolarizing cardioplegia; Cell volume regulation during cardioplegia; Transplant preservation (donor heart); Surgical robotics; Minimally invasive cardiac surgery

Clinical Interests:
Cardiac surgery, arrhythmia surgery,  off-pump cardiac surgery, coronary artery bypass graft (CABG) surgery, endoscopic CABG, beating heart surgery,  coronary artery revascularization, valve repair and replacement, minimally invasive cardiac surgery, myocardial preservation, surgical electrophysiology, transmyocardial laser revascularization,  TMR, HCM and robotic-assisted cardiac surgery.

Website:
cardiothoracicsurgery.wustl.edu

Email:
damianor@wustl.edu

Victor Davila RomanVictor G. Davila-Roman, M.D., F.A.C.C. F.A.S.E.
Professor of Medicine,
Anesthesiology, Radiology
Medical Director, Cardiovascular Imaging & Clinical Research Core Laboratory; Washington University School of Medicine


Clinical Interests:
Cardiomyopathy, magnetic resonance imaging, myocardiology, hypertension, vascular surgery, coronary artery disease, supervising and interpreting diagnostic tests, such as echocardiograms, stress echocardiograms, treadmill stress test, Holter, Event and Loop monitors

 

 




Website:
wuphysicians.wustl.edu

Email:
vdavila@wustl.edu

Mitchell FaddisMitchell N. Faddis, M.D., Ph.D.
Associate Professor of Medicine; Cardiovascular Division; Washington University School of Medicine
Director of Electrophysiology



Research Interests:
• Catheter ablation,
•  magnetic guidance,
•  congestive heart failure,
•  atrial fibrillation,
•  arrhythmia

Website:
wuphysicians.wustl.edu

Email:
faddism@wustl.edu

Steven GeorgeSteven C. George, M.D., Ph.D.
Elvera & William Stuckenburg
Professor of Technology & Human Affairs
Chair, Department of Biomedical Engineering

 

 

Research Interests:
• Pre-vascularization of implantable thick tissues;
• 3-D microphysiological systems to simulate cardiac and tumor tissue.

 

Website:
georgelab.bme.wustl.edu

Email:
scg@wustl.edu

Richard GrossRichard W. Gross, M.D., Ph.D.
Professor of Medicine, Chemistry, &
Developmental Biology
Division Chief, Bioorganic Chemistry & Molecular Pharmacology



Research Interests:

Chemical biology of membranes in health and disease

 

Website:
chemistry.wustl.edu/Gross

Email:
rgross@wustl.edu

Patrick JayPatrick Y. Jay, M.D., Ph.D.
Associate Professor of Pediatrics and Genetics
St. Louis Children’s Hospital
Washington University School of Medicine




Research Interests:
• Genetic and molecular interactions in cardiac development;
• Role of Nkx2-5 in the development and function of the conduction system;
•  Computational genomic analysis of cardiac gene regulation

Website:
research.peds.wustl.edu/Jay

Email:
jay_p@wustl.edu

Gilbert JostR. Gilbert Jost, M.D.
Professor of Radiology








Research Interests:
Radiology, medical imaging, new technologies, digital radiology, digital networking, x-rays, alternative screening


 

 

 

Website:
wuphysicians.wustl.edu


Email:

jostg@wustl.edu

Sandor KovacsSándor J Kovács, M.D., Ph.D.
Professor of Medicine, Cell Biology & Physiology
Adj. Prof. of Physics & Biomedical Engineering
Director & Founder, Cardiovascular Biophysics Laboratory


Research Interests:

• Theoretical (mathematical) biology and physiology.
• Characterization of physical properties of cardiovascular tissue
• Maximal information extraction from in-vivo physiologic signals
• Mathematical modeling of cardiovascular function
• Nonlinear dynamics, thermodynamics and optimization principles of cardiovascular unction
• Development of new technology for imaging and physiologic signal acquisition and processing



Websites:

cbl1.wustl.edu
cardiology.wustl.edu

Email:
sjk@wustl.edu

Douglas L. MannDouglas L. Mann, M.D.
Tobias and Hortense Lewin Professor and Chief, Cardiovascular Division,
Washington University School of Medicine
Cardiologist-in-Chief, Barnes Jewish Hospital

 


Clinical Interests:

Management of heart failure, transplant

 


Research Interests:
The molecular and cellular basis of heart failure, with a particular emphasis on the role of inflammatory mediators in disease progression in the failing heart.

Website:
wuphysicians.wustl.edu

Email:
dmann@wustl.edu

Scott MarrusScott Marrus, M.D., Ph.D.
Research Assistant Professor Preston M. Green Department of Electrical & Systems Engineering

 

 

 


Clinical Expertise:
Clinical cardiology; Echocardiography

Research Interests:

• Electrophysiology of adult human cardiac cells
• Dynamic current clamp
• Patient-specific induced pluripotent stem cell derived cardiomyocytes

Website:
ese.wustl.edu

Email:
smarrus@wustl.edu

Arye NehoraiArye Nehorai, Ph.D.
Eugene and Martha Lohman Professor, Preston M. Green Department of Electrical & Systems Engineering
Director, Center for Sensor Signal & Information Processing

 


Research Interests:

Statistical signal processing and imaging for security, defense, biomedicine, energy and the environment.




Website:
ese.wustl.edu

Email:
nehorai@wustl.edu

Jeanne NerbonneJeanne M. Nerbonne, Ph.D., F.A.H.A.
Alumni Endowed Professor of Molecular Biology & Pharmacology; Director, Center for Cardiovascular Research; Co-Director, Center for the Investigation of Membrane Excitability Diseases; Departments of Developmental Biology & Internal Medicine, Washington University Medical School


Research Interests:
Defining the molecular mechanisms controlling the properties, the cell surface expression, and the functioning of voltage-gated K+ (Kv) channels in the cardiovascular and nervous systems.

Website:
nerbonnelab.wustl.edu

Email:
jnerbonne@wustl.edu

Colin NicholsColin G. Nichols, Ph.D.
Carl Cori Professor
Department of Cell Biology and Physiology
Director, Center for the Investigation of Membrane Excitability Diseases
Washington University School of Medicine


Research Interests:
The molecular and cellular regulation of ion channels, and their role in linking cellular metabolism to electrical activity in various tissues.

 

 

 

 

 

 

 

 

Website:
nicholslab.wustl.edu

Email:
cnichols@wustl.edu

Amit NoheriaAmit Noheria, M.B.B.S., S.M.
Assistant Professor of Medicine, Cardiovascular Division, Washington University School of Medicine



 


Clinical Expertise:

Medical and catheter - based treatment of heart rhythm disorders like atrial fibrillation, ventricular and supra ventricular tachycardias. Catheter - based treatment for heart rhythm disorders in patients with congenital heart disease. Catheter - based pericardial interventions like ablation of rhythm abnormalities involving the outside surface of the heart. Implantation, management and extraction of cardiac el ectronic implantable devices like pacemakers, defibrillators and cardiac resynchronization therapy.

Research Interests:

Improvement and optimization of catheter - based treatments of heart rhythm disorders. Electrophysiologic mapping and ablation techniques for ventricular arrhythmias including premature ventricular beats and ventricular fibrillation. Epidemiology, treatments and clinical outcomes of heart rhythm disorders in patients with congenital heart disease. Clinical trials of novel technologies for management of heart rhythm disorders

Website:
wuphysicians.wustl.edu

Email:
anoheria@wustl.edu

Joseph a o sullivanJoseph A. O’Sullivan, Ph.D.
Samuel C. Sachs Prof. of Electrical Engineering Professor of Biomedical Engineering & Radiology
Professor and Dean of the UMSL/WUSTL Joint Undergraduate Engineering Program

Research Interests:
Information theory, estimation theory, and imaging science, with applications in object recognition, tomographic imaging, magnetic recording, radar, and formal languages.

 

 

Website:
essrl.wustl.edu

Email:
jao@wustl.edu

Daniel OryDaniel S. Ory, M.D.
Alan A and Edith L Wolff Distinguished Professor of Cardiology; Professor of Cell Biology& Physiology
Co-Director,
BioMed 21 Diabetic Cardiovascular Disease CenterWashington University School of Medicine


Research Interests:
• Study of regulation of cholesterol homeostasis;
• Role of cholesterol in atherosclerosis and neurodegeneration

 

 

Website:
dcdc.wustl.edu

Email:
dory@wustl.edu

Maria RemediMaria S. Remedi, Ph.D.
Assistant Professor, Department of Medicine
Division of Endocrinology, Metabolism & Lipid Research,
Department of Cell Biology & Physiology; Washington University School of Medicine



Research Interests:

• Study in vivo physiology in various mouse models of diabetes to unravel the underlying mechanisms of pancreatic β-cell failure in glucotoxic stages, and their consequences in both pancreatic and extra-pancreatic tissues


Website:
http://endo.wustl.edu/remedi-lab/

Email:
mremedi@dom.wustl.edu

Stacey RentschlerStacey L. Rentschler, M.D., Ph.D.
Assistant Professor of Medicine &
Developmental Biology
Cardiovascular Division
Washington University School of Medicine

 

Research Interests:
• Developmental Programming and Reprogramming of Conduction Tissue
• Molecular Basis of Congenital Heart Defects

 

Website:
rentschlerlab.wustl.edu

Email:
stacey.rentschler@wustl.edu

Clifford RobinsonClifford G. Robinson, M.D.
Associate Professor
Radiation Oncology
Chief of Service, Stereotactic Body Radiation Therapy (SBRT)





Research Interests:

• Optimizing dosing and delivery of radiotherapy with or without the addition of biologic modifiers for purposes of tumor control and normal tissue protection. See (.pdf) for more info.

Clinical Interests:
• Lung cancer, esophageal cancer, brain tumor, spine tumor, gamma knife, stereotactic body radiation therapy

Website:
wuphysicians.wustl.edu

Email:
crobinson@radonc.wustl.edu

Jean SchafferJean E. Schaffer, M.D.
Virginia Minnich Distinguished Prof. of Medicine
Director, Diabetic Cardiovascular Disease Center & Diabetes Research Training Center
Washington University School of Medicine


Research Interests:
• Molecular Mechanisms of Lipotoxicity
• Pathophysiological Models of Lipotoxicity
• Human Studies of Lipotoxicity in Diabetic Cardiovascular • Complications




Website:

schafferlab.wustl.edu


Email:

jschaff@wustl.edu

Richard SchuesslerRichard B. Schuessler, Ph.D.
Research Professor of Surgery (Cardiothoracic Surgery)
& Biomedical Engineering
Director, Cardiothoracic Surgery Research Laboratory
Washington University School of Medicine


Research Interests:

• Surgical treatment of atrial fibrillation;
•  Mechanisms of atrial fibrillation;
•  Inflammatory mechanisms in postoperative atrial fibrillation; • Basic cardiac electrophysiology;
•  Normal and abnormal sinus node electrophysiology;
•  Mapping of cardiac electrophysiology;
•  Animal models of cardiac arrhythmias.

Websites:
surgery.wustl.edu
cardiothoraciclabs.wustl.edu

Email:
schuesslerr@wustl.edu

Jingyi ShiJingyi Shi, Ph.D.
Research Assistant Professor
Department of Biomedical Engineering



 


Research Interests:

• Molecular mechanisms of ion channel activation
• Ion channels in association with diseases
• Discovery of channel-modifying compounds

 

 

 

Website:
research.engineering.wustl.edu

Email:
jshi22@wustl.edu

Jennifer SilvaJennifer N. A. Silva, M.D.
Assistant Professor of Pediatrics; Director of Pediatric Electrophysiology
Division of Pediatric Cardiology
Washington University School of Medicine


Research Interests:
• 
Clinical Applications of Noninvasive Electrocardiographic Imaging (ECGI)
•  Pediatric Cardiac Resynchronization Therapy

Clinical Interests:
• 
Clinical Electrophysiology/Arrhythmias
•  Inherited Channelopathies
•  Transcatheter ablations
•  Pacemakers/Defibrillators
•  Heart Failure and Cardiac Resynchronization Therapy
•  Sudden Cardiac Death

Website:
peds.wustl.edu

Email:
avari_j@wustl.edu

Jon SilvaJonathan R. Silva, Ph.D.
Assistant Professor, Department of Biomedical Engineering






Research Interests:
• Linking Changes in Molecular Conformation to Cardiac Function
• Spectroscopic Monitoring of Ion Channel Conformation
• Cardiac Ion Channel and Action Potential Modeling


 


 

Website:
silvalab.bme.wustl.edu

Email:
jonsilva@wustl.edu

Gautam SinghGautam K. Singh, M.D.
Professor of Pediatrics
Director of Non-Invasive Imaging Research
Co-Director of Echocardiography Laboratory
Washington University School of Medicine


Research Interests:
• Fetal cardiology
• Cardiac mechanics
• Strain imaging
• Cardiac MRI

Clinical Interests:
• Fetal cardiology,
• Preventive cardiology
• Hyperlipidemia
• Obesity in children
• Cardiac MRI

 

 

 

 

 

 

 

Website:
wuphysicians.wustl.edu

Email:
singh_g@wustl.edu

Timothy W. SmithTimothy W. Smith, D.Phil., M.D., F.A.C.C., F.H.R.S.
Associate Professor of Medicine
Cardiovascular Division,
Washington University School of Medicine
Clinical Cardiac Electrophysiologist,
Barnes-Jewish Hospital

Research Interests:
• Cardiac cellular and tissue electrophysiology and mechanism of arrhythmias;
• Treatment of arrhythmias, including pharmacologic therapy, ablation therapy, and implantable device therapy;
• Device implantation techniques;
• Prevention of sudden cardiac death.

Clinical Interests:
• Cardiac Electrophysiology
• Bradyarrhythmias, including pacemaker implantation and management
• Supraventricular tachyarrhythmias, evaluation and management, including catheter procedures for diagnosis (electrophysiology study) and therapy (ablation). 
• Ventricular tachyarrhythmias and sudden cardiac death, including risk stratification, pharmacologic therapy.
• Implantable Defibrillator (ICD) implantation and management.
• Catheter procedures for diagnosis (electrophysiology study) and therapy (ablation).
• Atrial fibrillation, evaluation and management, including both pharmacologic and nonpharmacologic therapy.
• Cardiac Resynchronization for congestive heart failure. 
Implantation and management of cardiac resynchronization pacemakers/defibrillators

Website:
cardiology.wustl.edu

Email:
tsmith@wustl.edu

Phyllis K. Stein, Ph.D., SEP Phyllis K. Stein, Ph.D., SEP
Associate Professor of Medicine
Director, Washington University School of Medicine HRV Lab








Research Interests:

Her work as the PI of the Washington University School of Medicine HRV (Heart Rate Variability) Laboratory has focused on using continuous ECG signals from Holter monitors, sleep studies, NICU and PICU signals and physiology labs to measure cardiac autonomic functioning. Her lab is one of the leading research HRV facilities in the world and they have developed sophisticated algorithms for examining heart rate patterns that go way beyond standard clinical measures.  They are experts in identifying and quantifying heart rate patterns that provide previously-unappreciated markers for healthy and unhealthy autonomic functioning in adults, children, babies and in genetically modified mice.  Her lab has data on about 20,000 subjects.

Her lab also offers training in HRV analytic techniques.  Her lab is currently creating an organized archive of studies and the signals, ECG-derived analyses, and projects or publications resulting from them.  The archive will also contain all of the HRV analyses that can be applied to each dataset. They have also published on ECG-waveform-based analyses, including QTVI and modified moving average T-wave alternans. 

Websites:
hrvlab.wustl.edu
cardiology.wustl.edu

Email:
pstein@wustl.edu

Jason TrobaughJason W. Trobaugh, D.Sc.
Lecturer
Department of Electrical & Systems Engineering


 


Research Interests:
• Probabilistic models for ultrasound images
• Model-based image analysis
• Treatment guidance applications for ultrasonic imaging
• Clinical applications of inverse electrocardiography
• Ultrasonic temperature imaging for management of thermal therapies

 

 

 

Website:
ese.wustl.edu

Email:
jasont@wustl.edu

George Van HareGeorge F. Van Hare, M.D.
Division Chief
Pediatric Cardiology
The Louis Larrick Ward Professor of Pediatrics

 

 




Research Interests:

• Multicenter clinical research in pediatric heart rhythm disorders; • Biology of atrioventricular node reentry;
• Mapping and ablation of post-operative atrial and ventricular tachycardia

Clinical Interests:
• Heart rhythm disorders in children, and in adults with congenital heart disease;
• Radiofrequency catheter ablation, cryoablation, pacemaker, implantable cardioverter-defibrillator, (ICD), implantation and follow-up.

 

 

Website:
peds.wustl.edu

Email:
vanhare_g@wustl.edu

Pamela WoodardPamela K. Woodard, M.D., F.A.C.R., F.A.H.A.,
F.C.C.P.
Director, Center for Clinical Imaging Research (CCIR); Professor of Radiology & Biomedical Engineering
Head, Advanced Cardiac Imaging (CT/MRI)
Washington University School of Medicine

Research Interests:
• Assessment of MRI techniques for the diagnosis of pulmonary 
thromboembolism and builds on the work of PIOPED II (assessment of multidetector spiral CT for PE detection)
• Assessment, characterization and prediction of stabiliy of atherosclerotic plaque
• Coronary CT Angiography 

Clinical Interests:
Cardiac CT and MRI, pulmonary embolism diagnosis


Websites:

ccir.wustl.edu

wuphysicians.wustl.edu

Email:
woodardp@wustl.edu

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