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Representative Publications
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Director - Yoram Rudy, Ph.D., F.A.H.A., F.H.R.S.
(Case Western Reserve University, 1978); The Fred Saigh Distinguished Professor of Engineering; Professor of Biomedical Engineering, Cell Biology & Physiology, Medicine, Radiology, and Pediatrics; Director of the Cardiac Bioelectricity and Arrhythmia Center (CBAC)
1) C. Luo and Y. Rudy, "A Dynamic Model of the Cardiac Ventricular Action Potential: I. Simulations of Ionic Currents and Concentration Changes” Circulation Research 1994; 74: 1071-1096; and
"A Dynamic Model of the Cardiac Ventricular Action Potential: II. Afterdepolarizations, Triggered Activity and Potentiation” Circulation Research 1994; 74: 1097-1113.
2) C.E. Clancy, Y. Rudy , "Linking a Genetic Defect to its Cellular Phenotype in a Cardiac Arrhythmia" Nature 1999; 400:566-569.
3) J. Silva, Y. Rudy, “Subunit Interaction Determines I Ks Participation in Cardiac Repolarization and Repolarization reserve” Circulation 2005;112:1384-1391.
4) C. Ramanathan, R.N. Ghanem, P. Jia, K. Ryu, Y. Rudy, “Electrocardiographic Imaging (ECGI): A Noninvasive Imaging Modality for Cardiac Electrophysiology and Arrhythmia” Nature Medicine 2004;10:422-428.
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Philip V. Bayly, Ph.D.
(Duke University, 1993); Professor of Mechanical and Aerospace Engineering, and of Biomedical Engineering, Washington University
1) P.V. Bayly , B.H. KenKnight, J.M. Rogers, E.E. Johnson, W.M. Smith and R.E. Ideker, "Spatial organization, predictability, and determinism in ventricular fibrillation," Chaos 1998; 8:103-115.
2) P.V. Bayly , B.H. KenKnight, J.M. Rogers, R.E. Hillsley, R.E. Ideker, and W.M. Smith, "Estimation of conduction velocity vector fields from epicardial mapping data," IEEE Trans. Biomedical Engineering 1988; 45:563-571.
3) A.R. Barnette, P.V. Bayly, S. Zhang, G.P. Walcott, R.E. Ideker, and W.M. Smith, "Estimation of 3-D conduction velocity vector fields from cardiac mapping data," IEEE Transactions on Biomedical Engineering 2000; 47(8): 1027-1035.
4) M.W. Kay, P.V. Bayly, R.B. Schuessler, "Effects of measurement error and sampling resolution on estimates of atrial tissue recovery parameters”, Annals of Biomedical Engineering 2000; 28:677-690.
5) J.M. Rogers and P.V. Bayly, "Quantitative analysis of complex rhythms”, in Cabo C., Rosenbaum D.S., eds. Quantitative Cardiac Electrophysiology. New York , Marcel Dekker. New York , 2002. |
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John P. Boineau, M.D.
(Duke University, 1959); Professor of Surgery, Medicine, and Biomedical Engineering
1) Boineau JP , Moore EN, “Evidence for propagation of activation across an accessory atrioventricular connection in types A and B pre-excitation”, Circulation 1970; 41:375-397.
2) Boineau JP, Moore EN, Spear JF, Sealy WC, “Basis of static and dynamic electrocardiographic variations in Wolff-Parkinson-White syndrome”, Am J Cardiol 1973; 32:32-45.
3) Boineau JP, Cox JL, “Slow ventricular activation in acute myocardial infarction. A source of re-entrant premature ventricular contractions”, Circulation 1973; 48:702-713.
4) Boineau JP, Schuessler RB, Mooney CR, Miller CB, Wylds AC, Hudson RD, Borremans JM, Brockus CW, “Natural and evoked atrial flutter due to circus movement in dogs”,Am J Cardiol 1980; 45:1167-1181.
5) Boineau JP, Canavan TE, Schuessler RB, Cain ME, Corr PB, Cox JL, “Demonstration of a widely distributed atrial pacemaker complex in the human heart”, Circulation 1988; 77:1221-1237. |
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| Jianmin Cui , Ph.D.
(State University of New York, 1992); Associate Professor on the Spencer T. Olin Endowment
1)
Shi, J. and Cui, J. (2001). Intracellular Mg2+ enhances the function of BK-type Ca2+- activated K+ channels. J. Gen. Physiol. 118, 589-605.[Commentary, 583-587].
2)
Shi, J. Krishnamoorthy, G., Yang, Y., Hu, L., Chaturvedi, N., Harilal, D., Qin, J., and Cui, J. (2002). Mechanism of magnesium activation of calcium-activated potassium channels. Nature 418, 876-880.
3)
Lei Hu, Jingyi Shi, Zhongming Ma, Gayathri Krishnamoorthy, Fred Sieling, Guangping Zhang, Frank Horrigan and Jianmin Cui (2003) Participation of the S4 Voltage Sensor in the Mg2+-Dependent Activation of Large Conductance (BK) K+ Channels. Proc. Natl. Acad. Sci., U.S.A. 100, 10488-10493.
4)
Cheri Deng, Fred Sieling, Hua Pan, and Jianmin Cui (2003) Ultrasound induced cell membrane porosity. Submitted to Ultrasound in Medicine and Biology.
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| Ralph J. Damiano , Jr., M.D.
(Duke University School of Medicine, 1980); John M. Shoenberg Professor; Surgery Chief of Cardiac Surgery
1) Prasad S. Maniar HS, Schuessler RB, Damiano RJ Jr. Chronic transmural atrial ablation using bipolar radiofrequency energy on the beating heart. J Thorac Cardiovasc Surg 2002; 124: 708-713.
2) Prasad SM, Maniar HS, Camillo CJ, Schuessler RB, Boineau JR, Sundt TM III, Cox JL, Damiano RJ Jr. The Cox-Maze III procedure for atrial fibrillation: Long-term efficacy in patients undergoing lone versus concomitant procedure. J Thorac Cardiovasc Surg 2003; 126:1822-1828.
3) Gaynor SL, Ishii Y, Diodato MD, Prasad S, Barnett K, Damiano NR, Wickline SA, Schuessler RB, Damiano RJ Jr. Successful performance of the Cox-Maze procedure on the beating heart using bipolar radiofrequency ablation: A feasibility study in animals. Ann Thorac Surg 2004; 78:1671-1677.
4) Gaynor SL, Diodato MD, Prasad SM, Ishii Y, Schuessler RB, Bailey MS, Damiano NR, Bloch JB, Damiano RJ Jr.: A prospective, single center clinical trial of a modified Cox-Maze procedure using bipolar radiofrequency ablation. J Thorac Cardiovasc Surg 2004; 128:535-542.
5) Ishii Y, Gleva MJ, Gamache MC, Schuessler RB, Boineau JP, Bailey MS, Damiano RJ Jr. Atrial tachyarrhythmias following the Maze procedure: Incidence and prognosis. Circulation 2004; 110 (suppl II):II-164-II-168.
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Igor R. Efimov, Ph.D.
(Moscow Institute of Physics and Technology, 1992); The Stanley and Lucy Lopata Associate Professor of Biomedical Engineering, Cell Biology & Physiology, and Radiology
1) Qu F., Zarubin F., Nikolski V.N., Efimov I.R., The Gurvich defibrillation waveform has lower defibrillation threshold than the Zoll waveform and the truncated exponential waveform in the rabbit heart, Can. J. Physiol. Phar. 2005, 83(2): 152-160.
2) Rothenberg F., Nikolski V.P., Watanabe M., Efimov I.R., Electrophysiology and anatomy of embryonic rabbit hearts before and after septation, Am. J. Physiol., 2005, 288: H344-51.
3) Dobrzynski H., Li J., Tellez J., Greener I.D., Nikolski V., Wright S., Parsons S., Jones S.A., Lancaster M.K., Yamamoto M., Honjo H., Takagishi Y., Kodama I., Efimov I.R., Billeter R., Boyett M.R., Three-dimensional model of the sinoatrial node including distribution of different cell types and a specialized exit pathway, Circulation, 2005, 111(7): 846-54.
4) Qu F., Li L., Nikolski V.P., Sharma V., Efimov I.R., Mechanisms of Superiority of Ascending Ramp Waveforms: New Insights into Mechanisms of Shock-induced Vulnerability and Defibrillation, AJP, 2005 (in press).
5) Jenkins M., Wade R.S., Rollins A.M., Efimov I.R., Optical Coherence Tomography imaging of the Purkinje Network. J.Cardiovasc. Electrophysiol., 2005 (in press). |
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Mitchell N. Faddis, M.D., Ph.D.
(Washington University, 1993); Assistant Professor of Medicine, Radiology; Clinical Cardiac Electrophysiologist, Barnes Hospital
1) M.N. Faddis , W. Blume, J. DehneJ, A. Hall, J. RauchJ, J. Sell, K.T. Bae, M. Talcott, and B.D. Lindsay, “Magnetically Guided Catheter for Endocardial Mapping and Radiofrequency Catheter Ablation” Circulation 2002; 106: 2980-2985.
2) M.N. Faddis, J. ChenJ, J. OsbornJ, M. Talcott, B. Lindsay, “Magnetic Guidance System for Cardiac Electrophysiology: A Prospective Trial of Safety and Efficacy in Humans”, Journal of the American College of Cardiology 2003; 42: 1952-58.
3) N. Sawhney, A. Waggoner, and M.N. Faddis, “A randomized prospective trial of atrioventricular delay programming for cardiac resynchronization therapy”, Heart Rhythm 2004; 1(5): 562-567.
4) A. Waggoner, L. de las Fuentes, M.N. Faddis, M. Gleva, V. Ramon-Davila, “Improvements in Left Ventricular Diastolic Function After Cardiac Resynchronization Therapy are Coupled to Response in Systolic Performance”, JACC 2004 (in press).
5) B. Knight, J. Coman, M.N. Faddis, S. Bailin, and P. Yong, “Longterm retention of cardiac resynchronization therapy”, JACC 2004; 44(1): 72-77.
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Richard W. Gross, M.D., Ph.D.
(New York University Medical School, 1976; Cardiology Fellow, Barnes Hospital, St. Louis, 1978-81; Washington University, St. Louis, Ph.D., 1982); Professor of Medicine, Chemistry, and Molecular Biology & Pharmacology; Director, Division of Bioorganic Chemistry and Molecular Pharmacology (Joint Appointment with the School of Medicine), Department of Internal Medicine, Department of Molecular Biology and Pharmacology and Department of Chemistry, Washington University School of Medicine
1)
Yang, J., Gibson, B., Snider, J., Jenkins, C.M., Han, X. and Gross, R.W., "Submicromolar Concentration of Palmitoyl-CoA Specifically Thioesterify Cysteine 244 in Glyceraldehyde-3-phosphate Dehydrogenase Inhibiting Enzyme Activity: A Novel Mechanism Potentially Underlying Fatty Acid Induced Insulin Resistance", Biochemistry 2005, 44:11903-11912.
2) Pike, L.J., Han, X., and Gross, R.W., "Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: A Shotgun Lipidomics Study", J. Biol. Chem. 2005, 280:26796-26804.
3) Yan, W., Jenkins, C.M., Han, X., Mancuso, D.J., Sims, H.F., Yang, K., and Gross, R.W., "The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2g (iPLA2g): Identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling", J. Biol. Chem. 2005, 280:26669-26679.
4) Han, X., Yang, K., Cheng, H., Fikes, K., and Gross, R.W., "Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization", J. Lipid Res. 2005,46:1548-1560.
5) Gross, R.W. , Jenkins, C.M., Yang, J., Mancuso, D.J., and Han, X., "Functional lipidomics: The roles of specialized lipids and lipid-protein interactions in modulating neuronal function", Prostag. Oth. Lipid M. 2005,77:52-64.
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Patrick Y. Jay, M.D., Ph.D.
(Washington University, 1995); Assistant Professor of Pediatrics and Genetics
1) Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O’Brien TX, Gourdie RG, Berul CI, Izumo S. Nkx2-5 Mutation Causes Anatomic Hypoplasia of the Cardiac Conduction System. J Clin Invest. 2004; 113:1130-1137.
2) Jay PY, Maguire CT, Wakimoto H, Berul CI, Izumo S. Absence of Msx2 does not affect cardiac conduction or rescue the conduction defects associated with Nkx2-5 mutation. J Cardiovasc Electrophysiol 2005; 16:82-85.
3) Jay PY, Rozhitskaya O, Tarnavski O, Sherwood MC, Dorfman AL, Ueyama U, Izumo S. Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes. Manuscript submitted, 2005.
4) Jay PY, Powell AJ, Sherwood MC, Izumo S. Nkx2-5 and congenital heart disease. In: Epstein CJ, Erickson RP and Wynshaw-Boris A, editors. The molecular basis of inborn errors of development. New York : Oxford University Press; 2003, pp. 607-614.
5) Jay PY, Harris BS, Buerger A, Rozhitskaya O, Maguire CT, Barbosky LA, Berul CI, O’Brien TX, Gourdie RG, Izumo S. Function follows form: Cardiac conduction system defects in Nkx2-5 mutation. Anat Rec. 2004; 280A: 966-72.
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Daniel Kelly, M.D.
(University of Illinois College of Medicine, 1982); Alumni Endowed Professor in Cardiovascular Diseases; Professor of Medicine, Pediatrics, and Molecular Biology & Pharmacology; Director, Center for Cardiovascular Research; Director of Cardiology; Co-Director, Cardiovascular Division, Department of Medicine, Washington University School of Medicine
1) Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, O Holloszy J, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1alpha Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis. PLoS Biol. 2005 Mar 15;3(4):1-16.
2) Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. A potential link between muscle peroxisome proliferator-activated receptor-α signaling and obesity-related diabetes. Cell Metabolism 2005 1:133-144.
3) Huss JM, Torra IP, Staels B, Giguere V, Kelly DP. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004 Oct;24(20):9079-91.
4) Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP . Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 5;94(4):525-33.
5) Kelly DP , Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes and Dev. 2004 Feb 15;18(4):357-68. Review |
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Sándor J Kovács, Ph.D., M.D.
(Ph.D., Caltech, 1977; M.D., University of Miami, 1979); Associate Professor of Medicine, Physiology, Physics and Biomedical Engineering
1) Meyer TE, Karamanoglu M, Ehsani EA, Kovács SJ. Left Ventricular Chamber Stiffness at Rest as a Determinant of Exercise Capacity in Heart Failure Subjects with Decreased Ejection Fraction. Journal of Applied Physiology. 2004; 97(5): 1667-72.
2) Chung CS, Karamanoglu M, Kovács SJ. The Duration of Diastole and its Phases as a Function of Heart Rate
During Supine Bicycle Exercise. American Journal of Physiology, Heart and Circulatory Physiology. 2004; 287(5): H2003-8.
3) Bowman AW, Kovács SJ. Prediction and Assessment of the Time-Varying Effective Pulmonary Vein Area via Cardiac MRI and Doppler Echocardiography. American Journal of Physiology, Heart and Circulatory Physiology. 2005 Jan; 288(1): H280-6.
4) Waters EA, Bowman AW, Kovács SJ. MRI determined left ventricular "crescent effect": a consequence of the slight deviation of the contents of the pericardial sack from the constant-volume state. American Journal of Physiology, Heart and Circulatory Physiology.,2005 Feb; 288(2): H848-53.
5) Wu Y, Bowman AW, Kovács SJ. Frequency-based analysis of diastolic function: The early, rapid-filling phase generates negative intraventricular wave reflections. Cardiovascular Engineering, 2005 ( In press). |
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| Bruce D. Lindsay , M.D.
Associate Professor of Medicine; Director, Clinical Electrophysiology Laboratory at Washington University
1) José Mauricio Sánchez, William T. Katsiyiannis, Brian F. Gage, Jane Chen, Mitchell N. Faddis, Marye J. Gleva, Timothy W. Smith, Bruce D. Lindsay, “Implantable cardioverter-defibrillator therapy improves long-term survival in patients with unexplained syncope, cardiomyopathy, and a negative electrophysiologic study”, Heart Rhythm 2005; Volume 2:367-373.
2) Narayan SM, Smith JP, Schechtman KB, Lindsay BD, Cain ME. “T-wave alternans phase following ventricular extrasystoles predicts arrhythmia-free survival”, Heart Rhythm 2005; 2:234-241.
3) Katsiyiannis WT. Waggoner AD. Barzilai B. Gage BF. Sanchez JM. Rogers JG. Lindsay BD. Gleva MJ. “Simplified peak power reserve in patients with an implantable cardioverter-defibrillator and advanced heart failure”, American Journal of Cardiology 2005; 95(2):286-8.
4) Hirshfeld JW Jr. Balter S. Brinker JA. Kern MJ. Klein LW. Lindsay BD. Tommaso CL. Tracy CM. Wagner LK. Creager MA. Elnicki M. Hirshfeld JW Jr. Lorell BH. Rodgers GP. Tracy CM. Weitz HH. American College of Cardiology Foundation. American Heart Association. American College of Physicians. ACCF/AHA/HRS/SCAI clinical competence statement on physician knowledge to optimize patient safety and image quality in fluoroscopically guided invasive cardiovascular procedures. A report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training. Journal of the American College of Cardiology 2004; 44(11):2259-82.
5) Faddis MN . Chen J. Osborn J. Talcott M. Cain ME. Lindsay BD. “Magnetic guidance system for cardiac electrophysiology: a prospective trial of safety and efficacy in humans”, Journal of the American College of Cardiology 2003;. 42(11):1952-8.
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Jeanne M. Nerbonne, Ph.D.
(Georgetown University, 1978); Alumni Endowed Professor of Molecular Biology and Pharmacology
1) H. Li, W. Guo, R.L. Mellor and J.M. Nerbonne, “KChIP2 modulates cell surface expression of Kv1.5-encoded K + channels”,Journal of Molecular and Cellular Cardiology, in press (2005).
2) F. Aimond, S.P. Kwak, K.J. Rhodes and J.M. Nerbonne, "Accessory Kvbeta1 Subunits differentially modulate the functional expression of voltage-gated K +channels in mouse ventricular myocytes, Circulation Research 96: 451-458 (2005).
3) S. Brunet, F. Aimond, H. Li, W. Guo, J. Eldstrom, D.A. Fedida, K.A. Yamada, and J.M. Nerbonne, “Heterogeneous expression of repolarizing voltage-gated K + currents in adult mouse ventricles”, Journal of Physiology, London 559: 103-120 (2004).
4) J.M. Nerbonne, "Studying cardiac arrhythmias in the mouse--a reasonable model for probing mechanisms?, Trends in Cardiovascular Medicine 14: 83-93 (2004).
5) H. Li, W. Guo, K.A. Yamada, and J.M. Nerbonne, “Selective elimination of one component of delayed rectification, I K,slow1, in mouse ventricular myocytes expressing a dominant negative Kv1.5 a-subunit”, American Journal of Physiology 286: H319-H328 (2004). |
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Colin G. Nichols, Ph.D.
(Leeds University, 1985); Professor of Cell biology and Physiology
1) L.R. Phillips, D. Enkvetchakul & C.G. Nichols (2003). Gating-dependence of inner pore access in inward rectifier K+ channels. Neuron 37, 953–962.
2) J.C. Koster, B.A. Marshall, N. Ensor, J.A. Corbett and C.G. Nichols (2000). Targeted Overactivity of b-cell KATP Channels Induces Profound Neonatal Diabetes. Cell 100, 645-654.
3) S.-L. Shyng. and C.G. Nichols. (1998). Phosphatidyl inositol phosphates control of nucleotide-sensitivity of KATP channels. Science 282, 1138-1141.
4) C.G. Nichols , S.-L. Shyng, A. Nestorowicz, et al. (1996). ADP as the intracellular regulator of insulin secretion. Science 272, 1785-1787.
5) A.N. Lopatin, E.N. Makhina, C.G. Nichols. (1994). Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature 372, 366-369.
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Edward K. Rhee, M.D.
(University of Pittsburgh School of Medicine, 1993); Assistant Professor of Pediatrics, Washington University School of Medicine; Director, Arrhythmia Services, St. Louis Children's Hospital
1) Collins KK, Rhee EK, Delucca JM, Alexander ME, Bevilacqua LM, Berul CI, Walsh EP, Mayer JE, Jonas RA, del Nido PJ, and Triedman JK, “Modification to the Fontan procedure for the prophylaxis of intra-atrial reentrant tachycardia: short-term results of a prospective randomized blinded trial”, Journal of Thoracic & Cardiovascular Surgery 127(3): 721-729, 2004 Mar.
2) Fitzgerald TN, Rhee EK, Brooks DH, and Triedman JK, ”Estimation of cardiac conduction velocities using small data sets”, Annals of Biomedical Engineering 31(3): 250-261, 2003 Mar.
3) Bevilacqua LM, Rhee EK, Epstein MR, and Triedman JK, “Focal ablation of chaotic atrial rhythm in an infant with cardiomyopathy”, Journal of Cardiovascular Electrophysiology 11(5: 577-581, 2000 May.
4) Frame LH, Rhee EK, Bernstein RC, and Fei H, “Reversal of reentry and acceleration due to double-wave reentry: two mechanisms for failure to terminate tachycardias by rapid pacing”, Journal of the American College of Cardiology 28(1: 137-145, 1996 Jul.
5) Frame LH, Rhee EK, Fei H, and Luchetti W, “Proarrhythmic and antiarrhythmic effects of flecainide on nonsustained reentry around the canine atrial tricuspid ring in vitro”, Pacing & Clinical Electrophysiology 14(11 Pt 2): 1728-1734, 1991 Nov. |
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Jean E. Schaffer , M.D.
(Harvard Medical School, 1986); Associate Professor of Medicine, Molecular Biology & Pharmacology
1) Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto TA, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. 2006. Mol Biol Cell 17: 770-778.
2)
Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of FATP1 in the heart causes lipotoxic cardiomyopathy. 2005. Circ Res 96:225-233.
3)
Listenberger LL, Han X, Lewis SL, Cases S, Farese RV, Ory DS, SchafferJE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. 2003. Proc Natl Acad Sci USA 100: 3077-3082.
4) Chiu H-C., Kovacs A., Ford D.A., Hsu F.-F., Garcia R., Herrero P., Saffitz J.E., Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. 2001. J Clin Invest 107: 813-22.
5) Listenberger L.L., Ory D.S., Schaffer JE. Palmitate-induced apoptosis occurs through a ceramide-independent pathway. 2001. J Biol Chem 276: 14890-14895. |
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Jason W. Trobaugh, D.Sc.
(Washington University in St. Louis 2000); Research Instructor in Medicine, Electrical and Systems Engineering
1) Arthur, R.M., Trobaugh, J.W., Straube, W.L., Moros, E.G. "Temperature Dependence of Backscattered Energy in Motion-Compensated Images", IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control., in review.
2) Trobaugh, J.W. , Arthur, R.M. "Estimation of Surface Pose with a Physically-Based Ultrasonic Image Model", IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control., in Press.
3) Cain , M.E. , Arthur, R.M., Trobaugh, J.W., "Detection of the fingerprint of the electrophysiological abnormalities that increase vulnerability to life-threatening ventricular arrhythmias", Journal of Interventional Cardiac Electrophysiology , vol. 9, no. 2, 103-18, 2003.
4) Arthur, R.M., Timbadia, K.J., Rauf, M.A., Trobaugh, J.W., "Effects of reducing the full-body surface to a torso model in forward and inverse electrocardiography", International Journal of Bioelectromagnetism, vol. 5, 312-313, 2003.
5) Trobaugh, J.W. , Arthur, R.M., "Methods for using ultrasound to generate a heart surface for electrocardiographic inverse problems", International Journal of Bioelectromagnetism, vol. 5, 314-315, 2003. |
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Pamela K. Woodard, M.D.
(Duke University School of Medicine, 1990); Associate Professor, Diagnostic Radiology, Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology
1) Hong C, Chrysant GS, Woodard PK, Bae KT. “Coronary artery stent patency assessed with in-stent contrast enhancement measurement in multi-detector row CT angiography.” Radiology, October, 233: 286-291, 2004.
2) Tang D, Yang C, Zheng J, Woodard PK , Sicard GA , Saffitz JE, and Yuan C. “3D MRI-based multi-component FSI models for atherosclerotic plaques.” Annals of Biomedical Engineering, 32: 947-960, 2004.
3) Singh JA, Woodard PK, Dávila-Román VG, Waggoner AD, Gutierrez FR, Zheng J, Eisen SA. “Cardiac magnetic resonance imaging abnormalities in systemic lupus erythematosus: A preliminary report.” Lupus, 14:137-144, 2005.
4) Hong C, Leawoods JC, Yablonskiy DA, Leyendecker JR, Bae KT, Pilgram TK, Woodard PK, Conradi MS, Zheng J. “Feasibility of combining MR perfusion, angiography, and (3)He ventilation imaging for evaluation of lung function in a porcine model.” Acad Radiol, 12: 202-209, 2005.
5) Zheng J, El Naqa E, Rowold FE, Pilgram T, Woodard PK, Saffitz JE, Tang D. “Quantitative Assessment of Vulnerability of Coronary Artery Plaques with MR Images and Biomechanics: A Pilot Study Ex Vivo.” Mag Res Medicine, 2005. (In press). |
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Kathryn A. Yamada, Ph.D., F.A.H.A.
(Georgetown University, 1982); Research Associate Professor of Medicine; Director of the Mouse Cardiovascular Phenotyping Core of the Center for Cardiovascular Research
1) Yamada, K.A. , Rogers , J.G., Sundset, R., Steinberg, T.H., Saffitz, J.E.: Upregulation of connexin45 in heart failure. J. Cardiovasc. Electrophysiol. 2003;14:1205-1212.
2) Betsuyaku, T., Kanno, S., Lerner, D.L., Schuessler, R.B., Saffitz, J.E., Yamada, K.A. : Spontaneous and inducible ventricular arrhythmias after myocardial infarction in mice. Cardiovasc. Pathol. 2004;13:156-164.
3) Yamada, K.A. , Kanter, E.M., Green, K.G., Saffitz, J.E.: Transmural distribution of connexins in rodent hearts. J. Cardiovasc. Electrophysiol., 2004;15:710-715.
4) Beauchamp P, Choby C, Desplantez T, de Peyer K, Green K, Yamada KA, Weingart R, Saffitz JE, Kléber AG: Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res 2004;95:170 178.
5) Shanker A, Yamada K, Green KG, Yamada KA, Saffitz JE. Matrix protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load. Circ Res 2005; in press.
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