CBAC Publications  

Representative or Recent Publications

Yoram Rudy, Ph.D., F.A.H.A., F.H.R.S., Director

1)  Silva JR, Pan H, Wu D, Nekouzadeh A, Decker K, Cui J, Baker NA, Sept D, Rudy Y. A Multiscale Model Linking Ion-Channel Molecular Dynamics and Electrostatics to the Cardiac Action Potential. Proc Natl Acad Sci USA (PNAS). 2009;106:11102-11106.Link

2) O’Hara TJ, Virág L, Varró A, Rudy Y. Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation. PLoS Computational Biology. 2011; 7(5): e1002061.doi:10.1371/journal.pcbi.1002061.Link

3)  Rudy Y. “Mathematical modeling of complex biological systems: From genes and molecules to organs and organisms: Heart”  In: Edward H. Egelman , editor: Comprehensive Biophysics, Volume 9, Simulation and Modeling. Harel Weinstein volume editor. Oxford: Academic Press, 2012. pp. 268-327.

4)  Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, Faddis MN, Lindsay BD, Smith TW, Rudy Y. Noninvasive Electroanatomic Mapping of  Human Ventricular Arrhythmias Using ECG Imaging (ECGI). Science Translational Medicine. 2011 (31 August); Volume 3 (issue 98):191-200 (98ra84).Link

5)  Rudy Y. Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates in Humans. Circulation Research. 2013 Mar 1;112(5):863-74. Link

R. Martin Arthur, Ph.D.

1 ) J. I. Laughner, F. S. Ng, M. S. Sulkin, R. M. Arthur and I. R. Efimov, "Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes,"  Am J Physiol: Heart Circ Physiol,  303:H753-H765, 2012. Link

2) R. M. Arthur, Y. Lin, S. Wang and J. W. Trobaugh, "Effects of Action Potential Duration on the Electrocardiogram in Type II Diabetes," International Journal of Bioelectromagnetism, December 2012.Link

3) R. M. Arthur, "Temperature Imaging Using Ultrasound", chapter 13 in Physics Of Thermal Therapy, Fundamentals and Clinical Applications, Editor: E. G. Moros, Series: Imaging In Medical Diagnosis And Therapy (William R. Hendee, Series Editor), Taylor & Francis, 2012.Link

4) R. M. Arthur and JW Trobaugh, "Electrocardiographic Textbooks Based on Template Hearts Warped using Ultrasonic Images",IEEE Transactions on Biomedical Engineering, 2012 Sep;59(9):2531-7.Link

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Philip Bayly, Ph.D.

1) P.V. Bayly , B.H. KenKnight, J.M. Rogers, E.E. Johnson, W.M. Smith and R.E. Ideker, "Spatial organization, predictability, and determinism in ventricular fibrillation," Chaos 1998; 8:103-115.Link

2) P.V. Bayly , B.H. KenKnight, J.M. Rogers, R.E. Hillsley, R.E. Ideker, and W.M. Smith, "Estimation of conduction velocity vector fields from epicardial mapping data," IEEE Trans. Biomedical Engineering 1988; 45:563-571.Link

3) A.R. Barnette, P.V. Bayly, S. Zhang, G.P. Walcott, R.E. Ideker, and W.M. Smith, "Estimation of 3-D conduction velocity vector fields from cardiac mapping data," IEEE Transactions on Biomedical Engineering 2000; 47(8): 1027-1035.Link

4) M.W. Kay, P.V. Bayly, R.B. Schuessler, "Effects of measurement error and sampling resolution on estimates of atrial tissue recovery parameters,” Annals of Biomedical Engineering 2000; 28:677-690.Link

5) J.M. Rogers and P.V. Bayly, "Quantitative analysis of complex rhythms,” in Cabo C., Rosenbaum D.S., eds. Quantitative Cardiac Electrophysiology. New York , Marcel Dekker. New York, 2002.

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Sanjeev Bhalla, M.D.

1) Schiebler ML, Bhalla S, Runo J, Jarjour N, Roldan A, Chesler N, François CJ., "Magnetic Resonance and Computed Tomography Imaging of the Structural and Functional Changes of Pulmonary Arterial Hypertension," J Thorac Imaging. 2013 May;28(3):178-195Link

2) Sanchez Mejia A, Singh H, Bhalla S, Singh GK, "Chronic Cyanosis Due to Persistent Left Superior Vena Cava Draining into the Left Atrium in the Absence of a Coronary Sinus," Pediatr Cardiol. 2013 Jan 19Link

3) Lubner MG, Simard ML, Peterson CM, Bhalla S, Pickhardt PJ, Menias CO, "Emergent and nonemergent nonbowel torsion: spectrum of imaging and clinical findings," Radiographics. 2013 Jan-Feb;33(1):155-73Link

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Daniel H. Cooper, M.D.

1) Zhang J, Cooper DH, Rudy Y, "Electrophysiologic mechanism of deteriorating cardiac function in a patient with inappropriate CRT indication and frequent ventricular ectopy," Pacing Clin Electrophysiol. 2013 Aug;36(8):1024-6.Link

2) Zhang J, Desouza KA, Cuculich PS, Cooper DH, Chen J, Rudy Y, "Continuous ECGI mapping of spontaneous VT initiation, continuation, and termination with antitachycardia pacing" Heart Rhythm. 2013 Aug;10(8):1244-5.Link

3) Marrus SB, Andrews CM, Cooper DH, Faddis MN, Rudy Y, "Repolarization changes underlying long-term cardiac memory due to right ventricular pacing: noninvasive mapping with electrocardiographic imaging" Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):773-81.Link

4) Zhang J, Desouza KA, Cuculich PS, Cooper DH, Chen J, Rudy Y, "Continuous ECGI mapping of spontaneous VT initiation, continuation, and termination with antitachycardia pacing," Heart Rhythm. 2012 Jan 2.Link
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Phillip S. Cuculich, M.D.

Desouza KA, Joseph SM, Cuculich PS, Ewald GA, Rudy Y, "Noninvasive mapping of ventricular activation in patients with transplanted hearts," J Electrocardiol. 2013 Nov-Dec;46(6):698-701.Link

Saint LL, Damiano RJ Jr, Cuculich PS, Guthrie TJ, Moon MR, Munfakh NA, Maniar HS, "Incremental risk of the Cox-maze IV procedure for patients with atrial fibrillation undergoing mitral valve surgery," J Thorac Cardiovasc Surg. 2013 Nov;146(5):1072-7. Link

Zhang J, Desouza KA, Cuculich PS, Cooper DH, Chen J, Rudy Y, "Continuous ECGI mapping of spontaneous VT initiation, continuation, and termination with antitachycardia pacing," Heart Rhythm. 2013 Aug;10(8):1244-5.Link

Robertson JO, Cuculich PS, Saint LL, Schuessler RB, Moon MR, Lawton J, Damiano RJ, Maniar HS, "Predictors and risk of pacemaker implantation after the Cox-maze IV procedure," Ann Thorac Surg. 2013 Jun;95(6):2015-20; disussion 2020-1. Link

Cuculich PS, Cooper DH, "Pericardial Invasion: Lessons learned from SAVR and TAVR, " J Am Coll Cardiol. 2014 Apr 22;63(15):1520-1Link

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Jianmin Cui, Ph.D.

1).  Lee H-C, Rudy Y, Chen P-Y, Sheu S-H, Chang J-G and Cui J, "Modulation of KCNQ1 Alternative Splicing Regulates Cardiac IKs Currents and Action Potential Repolarization" HeartRhythm 2013; 10:1220-1228.Link
2) Sun X, Shi J, Delaloye K, Yang X, Yang H, Zhang G, and Cui J, "The interface between membrane- spanning and cytosolic domains in BK channels is involved in b subunits modulation of gating, " J Neurosci. 2013; 33:11253-11261.Link

3)  Zaydman MA, Silva JR, Delaloye K, Li Y, Liang H, Larsson HP, Shi J, and Cui J, "Kv7.1 ion channels require PIP2 to couple voltage sensing to pore opening," Proc. Natl. Acad. Sci., U.S.A. 2013; 110:13180-13185.Link

4)  Li Y, Gao J, Lu Z, Delaloye D, Shi J, Bock K, Cohen IS, and Cui J, "Intracellular ATP binding is required to activate the slow activating K+ channel IKs" Proc. Natl. Acad. Sci., U.S.A. 2013; 110:18922-18927.Link

5 )  Li M, Chang S, Yang L, Shi J, McFarland K, Yang X, Moller A, Wang C, Zou X, Chi C and Cui J, "Conopeptide Vt3.1 preferentially inhibits BK channels containing β4 subunits via electrostatic interactions," J Biol Chem. 2014; 289:4735-4742.Link

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Ralph J. Damiano, Jr., M.D.

1) Robertson JO, Saint LL, Leidenfrost J, Damiano RJ Jr., "Illustrated techniques for performing the Cox-Maze IV procedure through a right mini-thoracotomy," Ann Cardiothorac Surg. 2014;3:105-116.Link

2) Saint LL, Lawrance CP, Leidenfrost JE, Robertson JO, Damiano RJ Jr., "How I do it: minimally invasive Cox-Maze IV procedure," Ann Cardiothorac Surg. 2014;3:117-119.Link

3) Robertson JO, Lee AM, Voeller RK, Damiano MS, Schuessler RB, Damiano RJ Jr., "Quantification of the functional consequences of atrial fibrillation and surgical ablation on the left atrium using cardiac magnetic resonance imaging," In press, Eur J Cardiothorac Surg2014 Feb 11. [Epub ahead of print]Link

4) Watanabe Y, Weimar T, Kazui T, Lee U, Schuessler RB, Damiano RJ Jr., "Epicardial ablation performance of a novel radiofrequency device on the beating heart in pigs," Ann Thorac Surg 2014;97:673-678.Link

5) Montecalvo A, Damiano RJ Jr., "Managing the left atrial appendage in the era of minimally invasive surgery," Intervent Cardiol Clin 2014; 3:229-238

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Victor Davila-Roman, Ph.D.

1) Joseph SM, Novak E, Arnold SV, Jones PG, Khattak H, Platts AE, Dávila-Román VG, Mann DL, Spertus JA, "Comparable performance of the kansas city cardiomyopathy questionnaire in patients with heart failure with preserved and reduced ejection fraction," Circ Heart Fail. 2013 Nov 1;6(6):1139-46.Link

2) Bruchas RR, de Las Fuentes L, Carney RM, Reagan JL, Bernal-Mizrachi C, Riek AE, Gu CC, Bierhals A, Schootman M, Malmstrom TK, Burroughs TE, Stein PK, Miller DK, Dávila-Román VG, "The St. Louis African American health-heart study: methodology for the study of cardiovascular disease and depression in young-old African Americans," BMC Cardiovasc Disord. 2013 Sep 8;13:66.Link

3) Cade WT, Overton ET, Mondy K, de las Fuentes L, Dávila-Román VG, Waggoner AD, Reeds DN, Lassa-Claxton S, Krauss MJ, Peterson LR, Yarasheski KE, "Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function," AIDS Res Hum Retroviruses. 2013 Aug;29(8):1151-60.Link
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Mitchell N. Faddis, M.D., Ph.D.

1) Faddis MN,  Bae K, Talcott M, Hall A, Dehne J, Rauch J, Sell J, Eng M, Lindsay B, "Pulmonary vein mapping with a novel magnetic catheter guided by a 3D-CT image." PACE. 2001; 24:13

2) Faddis MN,  Bae K, Talcott M, Hall A, Dehne J, Rauch J, Lindsay B, Klimek S 2002. Remote Control of a Magnetic Electrophysiology Catheter Allows Precise Intracardiac Navigation and Eliminates Radiation Exposure to the Operator. Journal of the American College of Cardiology. 2002; 39(5): 118A.Link

3) Faddis MN, Blume W, Dehne J, Hall A, Rauch J, Sell J, Bae KT, Talcott M., Lindsay B, "Magnetically Guided Catheter for Endocardial Mapping and Radiofrequency Catheter Ablation," Ciculation. 2002 Dec 3;106(23):2980-5.Link

4)Faddis MN, Hall AF, Prichard JB, Ambos D, Lindsay BD, "Precise navigation of an endocardial ablation catheter by a novel magnetic guidance system," PACE. 1998;22:773

5)Faddis MN, Hall AF., Talcott M, Dehne JR, Blume WM, Katsiyiannis WT, Lindsay BL, "Novel Magnetic Guidance System Eliminates Need For Conventional Catheter Steering Mechanisms," PACE. 2000; 23:586.

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Richard W. Gross, M.D., Ph.D.

1) Viader A, Sasaki Y, Kim S, Strickland A, Workman CS, Yang K, Gross R, Milbrandt J, "Aberrant schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy." Neuron. 2013 Mar 6;77(5):886-98.Link

2) Jenkins CM, Yang J, Gross RW, "Mechanism-based inhibition of iPLA2b demonstrates a highly reactive cysteine residue (C651) that interacts with the active site: Mass spectrometric elucidation of the mechanisms of underlying inhibition," Biochemistry. 2013, 52:4250-4263.Link

3) Liu X, Moon SH, Mancuso DJ, Jenkins CM, Guan S, Sims HF, Gross RW, "Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation, " Anal. Biochem. 2013 Nov 1;442(1):40-50.Link

4) Yang K, Dilthey BG, Gross RW, "Identification and quantitation of fatty acid double bond positional isomers: A shotgun lipidomics approach using charge-switch derivatization," Anal. Chem. 2013 Oct 15;85(20):9742-50.Link

5) Yang K, Kiebish MA, Gross RW, "Methodological Requirements for Lipidomics Research," Methodologies for Metabolomics: Experimental Strategies and Techniques, (N. Lutz, J.V. Sweedler and R.A. Weavers, Editors), 2013, 1st Edison, Cambridge University Press.

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Patrick Jay, M.D., Ph.D.

1) Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O’Brien TX, Gourdie RG, Berul CI, Izumo S. Nkx2-5 Mutation Causes Anatomic Hypoplasia of the Cardiac Conduction System. J Clin Invest. 2004; 113:1130-1137. Link

2) Jay PY, Rozhitskaya O, Tarnavski O, Sherwood MC, Dorfman AL, Lu Y, Ueyama U, Izumo S.: Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes. FASEB J. 19: 1495-7 (2005). Link

3) Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY.: Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 12: 392-398 (2006). Link

4) Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB.: Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 301: 602-614 (2007).Link

5) McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman R.D., Hewitt KA, Mollica JP, Zhang L, Zhang Y, Sherwood MC, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL.: Protective effects of exercise and PI3K(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA. 104: 612-617 (2007). Link

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R. Gilbert Jost, M.D.

1) Woodard PK, Slone RM, Sagel SS, Fleishman MJ, Gutierrez FR, Reiker GG, Pilgram TK, and Jost RG: Comparison of selenium-based digital and conventional screen-film chest radiographs for the detection of CT-proven pulmonary nodules. Radiology 1998. Link

2) Blaine GJ, Jost RG, Martin L, Weiss DA, Lehmann R, and Fritz K: Information and image integration: Project Spectrum. Proceedings - SPIE Medical Imaging 1998.Link

3) Woodard PK, Slone RM, Sagel SS, Fleishman MJ, Gutierrez FR, Reiker GG, Pilgram TK, Jost RG. Detection of CT-proved pulmonary nodules: comparison of selenium-based digital and conventional screen-film chest radiographs. Radiology. 1998 Dec;209(3):705-9.Link

4) Lawler LP, Fromke J, Jost RG, Evens RG. Results of and comments on the 2000 survey of the American Association of Academic Chief Residents in Radiology. Acad Radiol. 2001 Aug;8(8):777-81. Link

5) Jost RG, Blaine GJ, Fritz K, Bluma H, Sadhra S. Enhanced interfaces for web-based enterprise-wide image distribution. J Digit Imaging. 2002;15 Suppl 1:189-93.Link

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Sándor J Kovács, Ph.D., M.D.

1) Mossahebi S, Kovács SJ. Diastolic Function in Normal Sinus Rhythm vs. Chronic Atrial Fibrillation: Comparison by Fractionation of E-wave Deceleration Time into Stiffness and Relaxation Components. J AFIB 6(5): 13-19, 2014.Link

2) Mossahebi S, Kovács SJ. The isovolumic relaxation to early rapid filling relation: Kinematic model based prediction with in-vivo validation. Physiol Rep. 2(3): e00258, 2014.Link

3) Mossahebi S, Kovács SJ. Kinematic Modeling Based Decomposition of Transmitral Flow (Doppler E-wave) Deceleration Time into Stiffness and Relaxation Components. Cardiovascular Engineering & Technology, 5(1): 25-34, 2014.Link

4) Ghosh E, Kovács SJ.The Vortex Formation Time to Diastolic Function Relation: Assessment of Pseudonormalized vs. Normal Filling. Physiological Reports 1(6), 2013.Link

5) Mossahebi S, Shmuylovich L, Kovács SJ. The challenge of Chamber Stiffness Determination in Chronic Atrial Fibrillation vs. Normal Sinus Rhythm: Echocardiographic Prediction with Simultaneous Hemodynamic Validation. J AFIB. 6(3): 46-51, 2013.Link

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Mark D. Levin, M.D.

1) Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Lang D, Jacobson JT, Spurney CF, Liu F, Brown CB, Huang L, Beermann F, Muniswamy M, Epstein JA, Patel VV. A novel population of melanocyte-like cells in the heart and pulmonary veins are a source of triggers for atrial arrhythmogenesis. J Clin Invest. 2009;119(11):3420–3436.Link

2) Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, Gao E, Yu Z, Ferrari VA, Lu MM, Xu J, Zhang H, Hui Y, Cheng Y, Petrenko N, Yu Y, FitzGerald GA: Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7548-52. Link

3) Hawkins BJ, Levin MD, Petrenko, NB, Patel VV, Davis C, Thompson CB, Madesh M. A complex II regulated form of mitochondrial dysfunction in metabolically exhausted cells. J. Biol. Chem. 2010, 285:26494-26505.Link

4) Levin MD, Stephens P, Tanel RE, Vetter VL, Rhodes LA. Ventricular tachycardia in infants with structurally normal heart: a benign disorder. Cardiol Young. 2010 Dec;20(6):641-7.Link

5) Yu Z, Crichton I, Tang SY, Hui Y, Ricciotti E, Levin MD, Lawson JA, Puré E, FitzGerald GA (2012). Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A 2012 Apr 24;109(17):6727-32. Link

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Douglas L. Mann, M.D.

1) Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull Da, Stehlik J, Lewinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Dávila-Román VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM; NHLBI Heart Failure Clinical Research Network. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA. 2013 Dec 18;310(23):2533-43.Link

2) Givertz MM, Mann DL. Epidemiology and natural history of recovery of left ventricular function in recent onset dilated cardiomyopathies. Curr Heart Fail Rep. 2013 Dec;10(4):321-30.Link

3) Joseph SM, Novak E, Arnold SV, Jones PG, Khattak H, Platts AE, Dávila-Román VG, Mann DL, Spertus JA. Comparable performance of the kansas city cardiomyopathy questionnaire in patients with heart failure with preserved and reduced ejection fraction. Circ Heart Fail. 2013 Nov 1;6(6):1139-46. Link

4) Hasumi K, Aoki Y, Wantanabe R, Mann DL. Clinical response of advanced cancer patients to cellular immunotherapy and intensity-modulated radiation therapy. Oncoimmunology. 2013 Oct 1;2(10):e26381. Epub 2013 Oct 17.Link

5) Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang Lavine KJ, Kovacs A, Weinheimer C, Mann DL. Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart. J Am Heart Assoc. 2013 Sep 30;2(5).Link

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Scott Marrus M.D., Ph.D.

1) Marrus SB, DiAntonio A. Investigating the safety factor at an invertebrate neuromuscular junction. J Neurobiol. 2005; 63: 62-69.Link

2) Marrus SB, Nerbonne JM. Mechanisms linking short and long term electrical remodeling in the heart…is it a stretch? Channels. 2008; 2: 1-8. Link

3) Marrus SB, Cuculich PS, Wang W Nerbonne JM. Characterization of a novel, dominant negative KCNJ2 mutation associated with Andersen-Tawil syndrome.  Channels. 2011; 5(6): 500-509.Link

4) Marrus SB, Andrews CM, Cooper DH, Faddis MN, Rudy Y. Repolarization changes underlying long-term cardiac memory due to right ventricular pacing: noninvasive mapping with ECGI.  Circ. Arrhyth. Electrophysiol. 2012; 5(4): 773-781.Link

5) Marrus SB*, Laughner JI*, Zelmer E, Weinheimer C, MacEwan M, Cui S, Nerbonne J, Efimov I. A Fully Implantable Pacemaker for the Mouse: From Battery to Wireless Power. PLoS One. 2013; 8(10):e76291. *co-first authors.Link

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Jeanne M. Nerbonne, Ph.D., F.A.H.A.

1) Nerbonne JM, Kass RS.  Molecular physiology of cardiac repolarization. Physiol Rev 2005; 85: 1205-1253.Link

2) Yang KC, Foeger NC, Marrionneau C, Jay PY, McMullen JR, Nerbonne JM.  Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. J Physiol2010; 588: 5015-5032.Link

3) Marionneau C, Carrasquillo Y, Norris AJ, Isom L, Townsend RR, Link AJ, Nerbonne JM.  The sodium channel accessory subunit, Navb1, regulates neuronal excitability through modulation of voltage-gated K+ channels. J Neurosci 2012; 32: 5716-5727. Link

4) Foeger NC, Wang W, Mellor RL, Nerbonne JM. Stabilization of Kv4 protein by the accessory K+ channel interacting protein 2 (KChIP2) is required for the generation of native myocardial fast transient outward currents. J Physiol 2013; 591: 4149-4166.Link

5) Yang KC, Yamada KA, Patel AY, Topkara VK, Ewald GA, Mann DL, Nerbonne JM. Deep RNA sequencing reveals dynamic regulation of myocardial non-coding RNAs in the failing human heart and remodeling with mechanical circulatory support. Circulation 2014; 129:1009-1021.Link

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Colin G. Nichols, Ph.D.

1) Phillips LR, Enkvetchakul D, Nichols CG. Gating-dependence of inner pore access in inward rectifier K+ channels. Neuron. 2003 Mar 27;37(6):953-62.Link

2) Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG. Targeted Overactivity of b-cell KATP Channels Induces Profound Neonatal Diabetes. Cell. 2000 Mar 17;100(6):645-54.Link

3) Shyng SL, Nichols CG. Phosphatidyl inositol phosphates control of nucleotide-sensitivity of KATP channels. Science. 1998 Nov 6;282(5391):1138-41.Link

4) Nichols CG, Shyng SL, Nestorowicz A, Glaser BClement JP 4thGonzalez GAguilar-Bryan LPermutt MA, Bryan J. ADP as the intracellular regulator of insulin secretion. Science.1996 Jun 21;272(5269):1785-7.Link

5)Lopatin AN, Makhina EN, Nichols CG. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature. 1994 Nov 24;372(6504):366-9..Link

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Daniel S. Ory, M.D.

1) te Vruchte D, Speak AO, Wallom KL, Al Eisa N, Smith DA, Hendriksz CJ, Simmons L, Lachmann RH, Cousins A, Hartung R, Mengel E, Runz H, Beck M, Amraoui Y, Imrie J, Jacklin E, Riddick K, Yanjanin NM, Wassif CA, Rolfs A, Rimmele F, Wright N, Taylor C, Ramaswami U, Cox TM, Hastings C, Jiang X, Sidhu R, Ory DS, Arias B, Jeyakumar M, Sillence DJ, Wraith JE, Porter FD, Cortina-Borja M, Platt FM. Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker. J Clin Invest. 2014 Mar 3;124(3):1320-8. Link

2) Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R. Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. J Biol Chem. 2014 Apr 18;289(16):11095-110.Link 

3) Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS.Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry. 2014 May 13;53(18):3042-51.Link

4) Daily MD, Olsen BN, Schlesinger PH, Ory DS, Baker NA. Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers. J Chem Theory Comput. 2014 May 13;10(5):2137-2150.Link

5) Jiang H, Sidhu R, Fujiwara H, De Meulder M, de Vries R, Gong Y, Kao M, Porter FD, Yanjanin NM, Carillo-Carasco N, Xu X, Ottinger E, Woolery M, Ory DS, Jiang X. Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF. Lipid Res. 2014 May 27;55(7):1537-1548.Link

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Joseph A. O'Sullivan, Ph.D.

1) Pal D, O'Sullivan JA, Wu H, Janecek M, Tai YC. Linear and iterative reconstruction algorithms for novel PET-insert scanner. IEEE Nuclear Science Symposium Record, vol. 4, pp. 1938-1941, October 2005.Link

2) O'Sullivan JA, Benac J. Alternating Minimization Algorithms for Transmission Tomography. IEEE Transactions on Medical Imaging, vol. 26, no. 3, March 2007, pp. 283 – 297. Link

3) Westover MB,  O'Sullivan JA, Achievable rates for pattern recognition. IEEE Transactions on Information Theory, vol. 54,  no. 1, pp. 299 – 320, January 2008. Link

4) Chen M, O'Sullivan JA, Singla N, Sirevaag EJ, Kristjansson SD, Lai PH, Kaplan AD, Rohrbaugh JW. Laser Doppler Vibrometry Measures of Physiological Function:  Evaluation of Biometric Capabilities.  IEEE Transactions on Information Forensics and Security, vol. 5, no. 3, pp. 449-460, September 2010.  Link

5) Evans JD, Politte DG, Whiting BR, O'Sullivan JA, Williamson JF. Noise-resolution tradeoffs in x-ray CT imaging:  A comparison of penalized alternating minimization and filtered backprojection algorithms. Medical Physics, vol. 38, no. 3, 1444 – 1458, March 2011. Link

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Stacey Rentschler, M.D., Ph.D.

1) Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu M, Morley GE, Patel VV, Epstein JA. Notch Signaling Regulates Murine Atrioventricular Conduction and Formation of Accessory Pathways.  Journal of Clinical Investigation, 2011; 121(2):525-33.
Cover story with editorial commentary. Link

2) Rentschler S*, Yen AH, Lu J, Petrenko NB, Lu MM, Manderfield, LJ, Patel VV, Fishman GI, Epstein JA. Myocardial Notch Signaling Reprograms Cardiomyocytes to a Conduction-Like Phenotype. Circulation, 2012; 126(9):1058-66.Link
*corresponding author

3) Addis RC, Ifkovits JL, Pinto F, Kellam LK, Esteso P, Rentschler S, Christoforou N, Epstein JA, and Gearhart JD. Optimization of Direct Fibroblast Reprogramming to Cardiomyocytes using Calcium Activity as a Functional Measure of Success.  J Mol Cell Cardiol, 2013; 60C:97-106.Link

4) Smith AW, Hoyne JD, Nguyen PK, McCreedy DA, Aly H, Efimov IR, Rentschler S, Elbert DL. Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels.  Biomaterials, 2013; 34(28):6559-71 Link

5) Dawson M, Pajcini KV, D-altri T, Tu L, Jain R, Xu L, Chen M, Rentschler S, Shestova O, Werthheim GB, Kluke M, Aster JC, Gimotty P, Epstein JA, Speck N, Bigas A, Pear WS. Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal HSCs. Genes and Development, 2014;28(6):576-93.Link

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Jean E. Schaffer, M.D.

1) Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto TA, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. 2006. Mol Biol Cell 17: 770-778.Link

2) Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of FATP1 in the heart causes lipotoxic cardiomyopathy. 2005. Circ Res 96:225-233.Link

3) Listenberger LL, Han X, Lewis SL, Cases S, Farese RV, Ory DS, SchafferJE.  Triglyceride accumulation protects against fatty acid-induced lipotoxicity. 2003. Proc Natl Acad Sci USA 100: 3077-3082. Link

4) Chiu H-C., Kovacs A., Ford D.A., Hsu F.-F., Garcia R., Herrero P., Saffitz J.E., Schaffer JE.  A novel mouse model of lipotoxic cardiomyopathy. 2001. J Clin Invest 107: 813-22.Link

5) Listenberger L.L., Ory D.S., Schaffer JE. Palmitate-induced apoptosis occurs through a ceramide-independent pathway. 2001. J Biol Chem 276: 14890-14895.Link

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Richard B. Schuessler, Ph.D.

1) Saint LL, Lawrance CP, Okada S, Kazui T, Robertson JO, Schuessler RB, Damiano RJ Jr.  Performance of a novel bipolar/monopolar radiofrequency ablation device on the beating heart in an acute porcine model.  Innovations (Phila) 8(4):276-83, 2013.Link

2) Lawrance CP, Henn MC, Miller JR, Sinn LA, Schuessler RB, Damiano RJ Jr.  Comparison of the stand-alone Cox-Maze IV procedure to the concomitant Cox-Maze IV and mitral valve procedure for atrial fibrillation. Ann Cardiothorac Surg 3(1):55-61, 2014.Link

3) Janardhan AH, Gutbrod SR, Li W, Lang D, Schuessler RB, Efimov IR. Multistage electrotherapy delivered through chronically-implanted leads terminates atrial fibrillation with lower energy than a single biphasic shock. J Am Coll Cardiol 63(1):40-8, 2014.Link

4) Watanabe Y, Weimar T, Kazui T, Lee U, Schuessler RB, Damiano RJ Jr.  Epicardial ablation performance of a novel radiofrequency device on the beating heart in pigs.  Ann Thorac Surg 97(2):673-8, 2014.Link

5) Robertson JO, Lee AM, Voeller RK, Damiano MS, Schuessler RB, Damiano RJ.  Quantification of the functional consequences of atrial fibrillation and surgical ablation on the left atrium using cardiac magnetic resonance imaging.  Eur J Cardiothorac Surg 2014 Feb 11. [Epub ahead of print]Link

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Jennifer N. Silva, M.D.

1) Silva JN, Silva JR. Updates on the inherited cardiac ion channelopathies: from cell to clinical. Curr Treat Options Cardiovasc Med. 2012 Oct;14(5):473-89.Link

2) Silva JN, Vashist S, Van Hare GF. 3:2 antegrade atrioventricular block with AV nodal reentrant tachycardia: what is the mechanism and where is the block? Pacing Clin Electrophysiol. 2012 Jul;35(7):877-9.Link

3) Vashist S, Silva JN, Van Hare GF, Papez AL, Su WW, Rhee EK. Unusually high association of hypertrophic cardiomyopathy and complex heart defects in children with fasciculoventricular pathways. Pacing Clin Electrophysiol. 2012 Mar;35(3):308-13.Link

4) Ghosh S, Silva JN, Canham RM, Bowman TM, Zhang J, Rhee EK, Woodard PK, Rudy Y. Electrophysiologic substrate and intraventricular left ventricular dyssynchrony in nonischemic heart failure patients undergoing cardiac resynchronization therapy. Heart Rhythm. 2011 May;8(5):692-9. Link

5) Silva JN, Canter CE. Current management of pediatric dilated cardiomyopathy. Curr Opin Cardiol. 2010 Mar;25(2):80-7.Link

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Jonathan R. Silva, Ph.D.

1) Rudokas MW, Varga Z, Asaro AB, Schubert AR, Silva JR. The Xenopus Oocyte Cut-Open Vaseline Gap Voltage-Clamp Technique with Fluorometry. J Vis Exp. 2014 Mar 11;(85).Link

2) Zaydman MA, Silva JR, Delaloye K, Larsson HP, Cui J. PIP2 couples voltage sensing and pore opening in KV7.1 ion channels.Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13180-5.Link

3) Zhang HX*, Silva JR*, Lin YW, Verbsky JW, Lee US, Kanter EM, Yamada KA, Schuessler RB, Nichols CG. The Heterogeneity and Function of KATP Channels in Canine Hearts. Heart Rhythm,*Both authors contributed equally.2013 Oct;10(10):1576-83..Link

4) Silva JR and Goldstein SAN. Voltage Sensor Movements Describe Slow Inactivation of NaV Channels I:  Wild Type. J Gen Physiol. 2013 Mar;141(3):309-21.Link

5) Silva JR and Goldstein SAN. Voltage Sensor Movements Describe Slow Inactivation of NaV Channels II: L689I Mutants. J Gen Physiol. 2013 Mar;141(3):323-34.Link

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Gautam Singh, M.D., D.C.H., M.R.C.P., F.A.C.C.

1) Lipshultz SE, Adams MJ, Colan SD, Constine LS, Herman EH, Hsu DT, Hudson MM, Kremer LC, Landy DC, Miller TL, Oeffinger KC, Rosenthal DN, Sable CA, Sallan SE, Singh GK, Steinberger J, Cochran TR, Wilkinson JD; American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Basic Cardiovascular Sciences, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Radiology. Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions A Scientific Statement From the American Heart Association. Circulation 2013 Oct 22;128(17):1927-95. Link

2) Levy PT, Holland MR, Sekarski, TJ, Hamvas A, Singh GK. Feasibility and Reproducibility of Systolic Right Ventricular Strain Measurement by Speckle Tracking Echocardiography in premature infants. J Am Soc Echocardiogr 2013;26(10):1201-13.Link

3) Groh GK, Levy PT, Holland MR, Murphy JJ, Sekarski TJ, Myers CL, Hartman DP, Roiger RD, Singh GK. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014 Feb;27(2):163-71.Link

4) Levy PT, Sanchez A, Fowler S, Holland MR, Singh GK. Normal Ranges of Right Ventricular Systolic and Diastolic Strain Measures in Children: A Systematic Review and Meta-Analysis. J Am Soc Echocardiogr 2014 May;27(5):549-60. Link

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Timothy W. Smith, D. Phil., M.D.

1) Wang Y, Cuculich PS, Zhang J, Desouza KA, Vijayakumar R, Chen J, Faddis MN, Lindsay BD, Smith TW, Rudy Y. Noninvasive electroanatomic mapping of human ventricular arrhythmias with electrocardiographic imaging. Sci Transl Med. 2011 Aug 31;3(98):98ra84. Link

2) Bao M, Kanter EM, Huang RY, Maxeiner S, Frank M, Zhang Y, Schuessler RB, Smith TW, Townsend RR, Rohrs HW, Berthoud VM, Willecke K, Laing JG, Yamada KA. Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium. Channels (Austin). 2011 Nov-Dec;5(6):489-99.Link

3) Anastacio MM, Castillo-Sang M, Smith TW, Saad N, Lawton JS. Iatrogenic left internal thoracic artery to left subclavian vein fistula after excimer laser pacemaker lead extraction. J Thorac Cardiovasc Surg. 2012 Apr;143(4):e35-7.

4) Yamada KA, Smith TW. Photodynamic therapy: Shining new light on limiting the collateral damage of ablation? Heart Rhythm.2012 Sep;9(9):1510-1.

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Jason W. Trobaugh, D.Sc.

1) Trobaugh JW, Arthur RM. A Discrete-Scatterer Model for Ultrasonic Images of Rough Surfaces. IEEE Trans Ultrason Ferroelectr Freq Control.. 2000; 47:1520-1529.Link

2) Trobaugh JW, Arthur RM. A Physically-Based, Probabilistic Model for Ultrasonic Images Incorporating Shape, Microstructure and System Characteristics. IEEE Trans Ultrason Ferroelectr Freq Control. 2001; 48:1594-1605.Link

3) Cain ME, Arthur RM,Trobaugh JW. Detection of the fingerprint of the electrophysiological abnormalities that increase vulnerability to life-threatening ventricular arrhythmias. J Interv Card Electrophysiol. 2003; 9:103-118.Link

4) Arthur RM, Trobaugh JW, Straube WL, Moros EG. Temperature Dependence of Backscattered Energy in Motion-Compensated Images. IEEE Trans Ultrason Ferroelectr Freq Control. 2005; 52:1644-1652.Link

5) Trobaugh JW, Arthur RM, Straube WL, Moros EG. A Simulation Model for Ultrasonic Temperature Imaging Using Change in Backscattered Energy. Ultrasound Med. Biol. 2008 Feb; 34(2):289-298.Link

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George F. Van Hare, M.D.

1) Ceresnak SR, Tanel RE, Pass RH, Liberman L, Collins KK, Van Hare GF, Gates GJ, Dubin AM. Clinical and electrophysiologic characteristics of antidromic tachycardia in children with Wolff-Parkinson-White syndrome. Pacing Clin Electrophysiol. 2012 Apr;35(4):480-8. Link

2) Silva, J. N., Vashist, S., Van, Hare GF. 3:2 antegrade atrioventricular block with AV nodal reentrant tachycardia: what is the mechanism and where is the block?. Pacing Clin Electrophysiol.2012 Jul;35(7):877-9.Link

3) Collins KK, Schaffer MS, Liberman L, Saarel E, Knecht M, Tanel RE, Bradley D, Dubin AM, Paul T, Salerno J, Bar-Cohen Y, Sreeram N, Sanatani S, Law IH, Blaufox A, Batra A, Moltedo JM, Van Hare GF, Reed J, Ro PS, Kugler J, Anderson C, Triedman JK; Pediatric and Congenital Electrophysiology Society. Fascicular and Nonfascicular Left Ventricular Tachycardias in the Young: An International Multicenter Study. J Cardiovasc Electrophysiol. 2013 Jun;24(6):640-8.Link

4) Longmuir PE, Brothers JA, de Ferranti SD, Hayman LL, Van Hare GF, Matherne GP, Davis CK, Joy EA, McCrindle BW; American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young.
Promotion of Physical Activity for Children and Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association. Circulation. 2013 May 28;127(21):2147-59. Link

5) Walsh EP, Bar-Cohen Y, Batra AS, Dick M 2nd, Erickson C, Fish F, Hamilton RM, Kanter RJ, Reed JH, Van Hare GF, Vetter VL, Webster G, Walsh EP, Bar-Cohen Y, Hamilton RM, Reed JH, Van Hare GF; Training and Credentialing Committee of the Pediatricand Congenital Electrophysiology Society. Recommendations for advanced fellowship training in clinical pediatric and congenital electrophysiology: a report from the training and credentialing committee of the pediatric and congenital electrophysiology society.
Heart Rhythm. 2013 May;10(5):775-81.Link

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Lihong Wang, Ph.D.

1) * Wang LD, Xia J, Yao J, Maslov K, Wang LV. Ultrasonically encoded photoacoustic flowgraphy in biological tissue. Physical Review Letters. 2013 Nov 12; 111, 204301.Link

2) Y. Shen, L. V. Wang, and J.-T. Shen, “Deep subwavelength optical imaging using correlated nano-torches,” Applied Physics Letters 103, 201119 (Nov. 2013).Link

3) Xia J, Li G, Wang L, Nasiriavanaki M, Maslov K, Engelbach JA, Garbow JR, Wang LV. Wide-field two-dimensional multifocal optical-resolution photoacoustic-computed microscopy. Opt Lett. 2013 Dec 15;38(24):5236-9.Link

4) Yao J, Ke H, Tai S, Zhou Y. Wang LV. Absolute photoacoustic thermometry in deep tissue. Opt Lett. 2013 Dec 15;38(24):5228-31.Link

5) Lalwani G, Cai X, Nie L, Wang LV, Sitharaman B. Graphene-based contrast agents for photoacoustic and thermoacoustic tomography. Photoacoustics. 2013 Dec 1;1(3-4):62-67.Link

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Samuel A. Wickline, M.D.

1) Pan D, Schirra CO, Wickline SA, Lanza GM. Multicolor computed tomographic molecular imaging with noncrystalline high-metal-density nanobeacons. Contrast Media Mol Imaging. 2014 Jan-Feb;9(1):13-25. Link

2) Hood JL, Scott MJ, Wickline SA.Maximizing exosome colloidal stability following electroporation. Anal Biochem. 2014 Mar 1;448:41-9. Link

3) Pan D, Schmieder AH, Wang K, Yang X, Senpan A, Cui G, Killgore K, Kim B, Allen JS, Zhang H, Caruthers SD, Shen B, Wickline SA, Lanza GM. Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using α(v)β₃-targeted theranostic nanoparticles. Theranostics. 2014 Mar 11;4(6):565-78. Link

4) Jallouk AP, Moley KH, Omurtag K, Hu G, Lanza GM, Wickline SA, Hood JL. Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. PLoS One. 2014 Apr 18;9(4):e95411.Link

5) Bibee KP, Cheng YJ, Ching JK, Marsh JN, Li AJ, Keeling RM, Connolly AM, Golumbek PT, Myerson JW, Hu G, Chen J, Shannon WD, Lanza GM, Weihl CC, Wickline SA. Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function. FASEB J. 2014 May;28(5):2047-61. Link

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Pamela K. Woodard, M.D.

1. Truong QA, Hayden D, Woodard PK, Kirby R, Chou ET, Nagurney JT, Wiviott SD, Fleg JL, Schoenfeld DA, Udelson JE, Hoffmann U. Sex Differences in the Effectiveness of Early Coronary Computed Tomographic Angiography Compared With Standard Emergency Department Evaluation for Acute Chest Pain: The Rule-Out Myocardial Infarction With Computer-Assisted Tomography (ROMICAT)-II Trial. Circulation. 2013 Jun 25;127(25):2494-502. Link

2) Lau JM, Laforest R, Priatna A, Sharma S, Zheng J, Gropler RJ, Woodard PK. Demonstration of intermittent ischemia and stunning in hibernating myocardium. J Nucl Cardiol. 2013 Oct;20(5):908-12. Link

3) Earls JP, Woodard PK, Abbara S, Akers SR, Araoz PA, Cummings K, Cury RC, Dorbala S, Hoffmann U, Hsu JY, Jacobs JE, Min JK. ACR Appropriateness Criteria Asymptomatic Patient at Risk for Coronary Artery Disease. J Am Coll Radiol. 2014 Jan;11(1):12-9. Link

4) Huang X, Yang C, Zheng J, Bach R, Muccigrosso D, Woodard PK. Tang D.Higher critical plaque wall stress in patients who died of coronary artery disease compared with those who died of other causes: A 3D FSI study based on ex vivo MRI of coronary plaques. J Biomech. 2014 Jan 22;47(2):432-7. Link

5) Luehmann HP, Pressly ED, Detering L, Wang C, Pierce R, Woodard PK. Gropler RJ, Hawker CJ, Liu Y. PET/CT Imaging of Chemokine Receptor CCR5 in Vascular Injury Model Using Targeted Nanoparticle. J Nucl Med. 2014 Apr;55(4):629-34.Link

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