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Mechanism behind heartbeat regulation, heart function uncovered

Jianmin Cui, Billy Powei Kang, how CaM and PIP2 orchestrate large-scale molecular movement
The team’s findings suggest CaM and PIP2 facilitate the KCNQ1 cytoplasmic domain to undergo large conformational change during voltage-dependent activation to open the channel, as illustrated by the structural depiction (top left) and cartoon (bottom left) of the channel. This movement may control KCNQ1 current activation speed (blue, bottom right) to help terminate action potential (gray, top right).
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