For biomedical engineer Yoram Rudy, a new chapter awaits
It’s no wonder that after such a long, accomplished and productive career, Yoram Rudy is not quite ready to retire from his life’s work. Yes, he stepped down at the end of 2022 from his role as director of the Cardiac Bioelectricity and Arrhythmia Center — which he founded in 2004 — to become emeritus professor, but he sees this next step as yet another opportunity to begin anew. With a life defined by an inquisitiveness that has furthered the field of biomedicine, Rudy has trained and inspired a new generation of bioengineers as they make their own discoveries in service to humanity.
Radiotherapy repairs irregular rhythms in those with life-threatening heart arrhythmia.
New research from Washington University School of Medicine in St. Louis suggests that radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure.
CBAC Jianmin Cui leads a multi-institutional team to make this discovery. Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Weikai Li, associate professor of biochemistry and molecular biophysics at the School of Medicine, along with CBAC Member Michael J. Greenberg, assistant professor of biochemistry and molecular biophysics, and Michael L. Gross, professor of chemistry in Arts & Sciences, and of immunology and of medicine at the School of Medicine, received a three-year $750,000 grant from American Heart Association for their research titled “Interdisciplinary structural studies of iron homeostasis in cardiovascular health.”
On December 8, 10:00 am, please join us for this virtual seminar by Elisabetta Cerbai, Professor of Pharmacology and the Director of the Center for Molecular Medicine at the University of Florence, Italy.
Richard Schuessler, PhD, Director of the Cardiac Surgical Research Laboratory, retires from the Department of Surgery in October 2020, after an accomplished 35-year career at Washington University School of Medicine in St. Louis.
CBAC Members, Jennifer and Jon Silva have developed a hologram that visualises a patient’s heart while they are in the operating theatre. They were featured on BBC News. Click on the title or image for their BBC News video.
Holographic display improves physician accuracy when treating irregular heartbeat. CBAC members, Jennifer N. Avari Silva, MD, associate professor of pediatrics at the School of Medicine, and Jonathan Silva, associate professor of biomedical engineering in the McKelvey School of Engineering, co-led a team that tested a Microsoft HoloLens headset with custom software during cardiac ablation procedures on patients at St. Louis Children’s Hospital.
CBAC members, Jon Silva’s and Jeanne Nerbonne’s lab will investigate a novel protein component of the cardiac sodium channels to determine its functional effects in the physiological regulation and pathophysiological remodeling of electrical propagation of the heart.
Rudy lab conducts first study of electromechanics of healthy, living human hearts. While there have been numerous studies of abnormalities in the human heart, there have not been studies of the electromechanics of healthy adult hearts — until now.
A single high dose of radiation aimed at the heart significantly reduces episodes of a potentially deadly rapid heart rhythm, according to results of a phase one/two study at Washington University School of Medicine in St. Louis. This article features the work of CBAC members Clifford G. Robinson, MD, an associate Professor of radiation oncology and of cardiology, and Phillip S. Cuculich, MD, an associate Professor of Cardiology and of radiation oncology.
Douglas L. Mann, the Tobias & Hortense Lewin Distinguished Professor of Medicine (Cardiovascular Division) will deliver the keynote address at the Acute Cardiac Unloading and Recovery’s 4th Annual Symposium. The symposium will take place on August 29-30, 2019 in Paris, France.
On Wednesday, April 10, 2019, the Skandalaris Center hosted the second annual Skandy Awards. The awards welcomed of the WashU and St. Louis community to celebrate the innovative, creative, and entrepreneurial achievements of Washington University students, faculty and alumni.
CBAC members, Drs. Phillip Cuculich and Jennifer Silva were awarded the Skandalaris Center Awards in Innovation.
Recognized for accomplishments in cardiovascular imaging and research
Pamela K. Woodard, MD, CBAC member and professor of radiology recognized for her expertise in cardiothoracic radiology at Washington University School of Medicine in St. Louis, has been named the inaugural Hugh Monroe Wilson Professor of Radiology.
CBAC member Jennifer Silva, MD, a pediatric electrophysiologist at Washington University School of Medicine in St. Louis, treats children with abnormal heart rhythms. She has co-founded a startup company that is developing technology intended to help doctors see real-time 3D holograms of the heart during procedures to fix erratic heart rhythms.
CBAC member, Arthur’s long-standing place in the Department of Electrical & Systems Engineering will come to an end later this year when he leaves the university to continue working on his health care startup, ATM Cardiac Diagnostics LLC, which he formed along with fellow CBAC member Jason Trobaugh, professor of the practice in electrical & systems engineering, and Scott Marrus, MD, former CBAC member and a Washington University cardiologist at Barnes-Jewish Hospital.
In celebration of many years of breakthrough science, the alumni of the Yoram Rudy Lab organized a reunion on May 23-24, 2018 in St. Louis. Speakers and participants included CBAC members, Phillip Cuculich, Jianmin Cui, Jennifer Silva, Jonathan Silva, and Richard Schuessler.
After new technology recently revealed the structure of the protein, the lab of CBAC member Jianmin Cui, professor of biomedical engineering in the School of Engineering & Applied Science, will collaborate with two others to take an unprecedented look into its molecular mechanisms potentially leading to the development of new drugs for these and other conditions.
Scientists studying link between rare disease and heart health
CBAC member, Colin Nichols, the Carl F. Cori Professor of Cell Biology and Physiology, has received a grant to study how the genetic mutations underlying Cantu syndrome are linked to cardiovascular disease.
Engineers find unexpected results during cardiac research. This article features CBAC members Jonathan Silva, assistant professor of biomedical engineering, and Jeanne Nerbonne, Alumni Endowed Professor of Molecular Biology and Pharmacology and director of the Center for Cardiovascular Research at Washington University’s School of Medicine.
Silva, Nerbonne and Zoltan Varga from the University of Debrecen in Hungary worked with collaborators to take a closer look at the sodium ion channels responsible for creating the electrical signal that makes the heartbeat.They found that certain sodium subunits attached to the main protein in different places. It was an unexpected result that could lead to better drug delivery and efficacy for patients with heart arrhythmia.
CBAC member Jianmin Cui, professor of biomedical engineering, and collaborators in three labs at WashU are studying the BK channel, which has been found to be important in regulating neuronal function and blood pressure.
The CardioInsight ECGI system was cleared by the FDA. After 30 years of development and validation in CBAC Director Yoram Rudy’s laboratory, he hopes to see ECGI in clinical use in hospitals, helping to treat cardiac patients.
CBAC member George F. Van Hare III, MD, director of the Division of Pediatric Cardiology at Washington University School of Medicine in St. Louis, has been named president-elect of the Heart Rhythm Society, a global research and education group focused on cardiac rhythm disorders.
CBAC member Arye Nehorai, the Eugene and Martha Lohman Professor of Electrical Engineering and chair of the Department of Electrical & Systems Engineering in the School of Engineering & Applied Science, and his team have developed the first 3-D multiscale mathematical model of the electrophysiology of a woman’s contractions as they begin from a single cell to the myometrium, or uterine tissue, into the uterus
While working a Case Western Reserve University, CBAC Director Yoram Rudy, PhD had the idea for a game-changing cardiac monitoring device–a vest filled with more than 200 sensors that could detect the heart’s electrical activity. While standard 12-lead EKGs had become the gold standard for detecting many heart problems, EKGs still can miss cardiac problems because they only probe electrical potential at a limited number of points on the body.
On Friday, August 28th, the Cardiac Bioelectricity & Arrhythmia Center (CBAC) of Washington University held a one-day symposium celebrating its 10th anniversary. The symposium addressed basic research and clinical issues in the field of cardiac arrhythmias. Faculty included speakers from Washington University and guests from all around the world.
Medtronic acquired CardioInsight Technologies, developer of a clinical noninvasive imaging system, called ECGI, for noninvasive mapping of the electrical activity of the heart and cardiac arrhythmias. The ECGI concept and methodology were developed in Professor Yoram Rudy’s laboratory with support from the NIH – National Heart, Lung and Blood Institute.
Findings could lead to better treatment for cardiac arrhythmia and long QT syndrome.CBAC member Jianmin Cui, PhD, has received a nearly $1.7 million grant from the National Institutes of Health (NIH) to study the molecular bases for the function of potassium channels vital for the heart, brain, inner ear and other tissues.