Our research projects cover the entire spectrum from molecular and cellular processes to mechanisms, diagnosis and treatment of arrhythmias in patients. The cross-disciplinary structure of the CBAC promotes collaborations between researchers and clinicians and fosters a multiple-approach strategy to the study, diagnosis and treatment of cardiac arrhythmias. Approaches include molecular, single-cell and whole-animal experiments, mathematical modeling and computer simulations, and patient studies during imaging, catheterization and open-heart surgery. Among the state-of-the-art techniques employed are genetics, biomolecular structural analysis, patch clamp recordings from single ion channels, ion-selective electrode measurements, high resolution electrical mapping, optical mapping of cardiac activation and cell-calcium, supercomputing and computer graphics, signal processing and image analysis.

Faculty Research Interests and Labs:

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Yoram Rudy Lab

Yoram Rudy Lab

Cardiac Bioelectricity and Arrhythmia Center (CBAC) Director’s Lab

Research Interests:

    •  Cardiac Bioelectricity
    •  Cardiac Electrophysiology and Arrhythmias
    •  Computational Biology and Mathematical modeling
    •  Cardiac Imaging and Mapping

Lab website

Martin Arthur Lab

Martin Arthur Lab

Research Interests:

    •  Electrocardiography
    •  Ultrasonics
    •  Auditory Neurophysiology
    •  Technology in Healthcare

Lab website

C. William Balke Lab

C. William Balke Lab

Research Interests:

    • Cardiac calcium homeostasis

    • SR calcium regulation

Experimental Techniques:

    • The patch clamp technique
    (whole-cell & single channel variations)
    • Epifluorescence microscopy with ion-selective fluorescent indicators
    • Fash photolysis of “caged” compounds
    • Laser scanning confocal microscopy
    (single & two photon)
    • Mathematical modeling

Lab website

Philip Bayly Lab

Philip Bayly Lab

Research Interests:

  • • Biomechanics of Brain Development
    • Dynamic Brain Deformation and Traumatic Brain Injury
    • Mechanics of Cilia and Flagella

Lab website

Sanjeev Bhalla Lab

Sanjeev Bhalla Lab

Research Interests:

    •  Chest Radiology
    •  Body Computed Tomography
    •  Emergency Radiology
    •  Cardiac Imaging
    •   Radiology

Clinical Interests:

    •   Body computed tomography/magnetic resonance
    •   Chest biopsies
    •   Special interest in cardiac imaging

Research profile

Daniel Cooper Lab

Daniel Cooper Lab

Research Interests:

    •  Prevention of sudden cardiac death (SCD)
    •  Mechanisms that lead to ventricular arrhythmias and cardiac arrest
    •  Long and short QT syndromes, Brugada syndrome, early repolarization syndrome, catecholaminergic polymorphic VT (CPVT), idiopathic VT/VF
    •  Cardiomyopathy

Clinical Interests:

    •  Cardiac arrhythmias
    •  Implantable defibrillators
    •  Heart rhythm disorders
    •  Pacemakers
    •  Electrocardiographic imaging

Research profile

Phillip Cuculich Lab

Phillip Cuculich Lab

Research Interests:

    • Electrocardiographic Imaging (ECGI)
    • HYBRID-AF Procedure
    • Risks and Benefits of Implantable Defibrillators (ICD’s)
    • Cardiogenic Syndromes

Clinical Interests:

    • Arrhythmias
    • Inherited/genetic syndromes
    • Sudden cardiac death
    • Atrial fibrillation
    • Ventricular tachycardia
    • Electrophysiology
    • Cardiovascular disease

Research profile

Jianmin Cui Lab

Jianmin Cui Lab

Research Interests:

    • Molecular mechanisms of ion channel activation
    • Ion Channels in Physiology and Disease
    • Discovery of channel-modifying compounds

Lab website

Aarti Dalal Lab

Aarti Dalal Lab

Research and Clinical Interests:

    • Pediatric heart rhythm disorders
    • Electrophysiology studies
    • Catheter ablation
    • Pacemaker/defibrillator implantation

Research profile

Ralph Damiano Lab

Ralph Damiano Lab

Research Interests:

    • Surgical treatment of arrhythmias
    • Myocardial protection
    • Atrial fibrillation

Clinical Interests:

    • Cardiac surgery, arrthymia surgery, beating heart surgery, minimally invasive cardiac surgery
    • Endoscopic coronary artery bypass grafting
    • Coronary artery revascularization
    • Valve repair and replacement
    • Myocardial preservation
    • Surgical electrophysiology
    • Transmyocardial laser revascularization (TMR)
    • Hypertrophic Cardiomyopathy (HCM) and hypertrophic cardiomyopathy (HCM) with obstruction

Research profile

Abhinav Diwan Lab

Abhinav Diwan Lab

Research Interests:

    • Understanding the role of lysosomes in health and disease
    • Use both invertebrate and vertebrate model systems to perturb and interrogate lysosome biology
    • Develop targeted therapies that can harness lysosome function to prevent and treat cardiomyopathy, heart failure,  Alzheimer’s disease and diabetes

Clinical Interests:

    • General cardiology and echocardiography
    • Understand the role of lysosome dysfunction and protein aggregation in patients with cardiomyopathy and heart failure
    • Characterizing cardiovascular complications in patients with COVID-19

Lab website

Victor Davila-Roman Lab

Victor Davila-Roman Lab

Research Interests:

    • Hypertensive heart disease (HHD)-endophenotypes

Clinical Interests:

    • Cardiomyopathy
    • Magnetic resonance imaging
    • Myocardiology
    • Hypertension
    • Vascular surgery
    • Coronary artery disease
    • Supervising and interpreting tests, such as stress echocardiograms
    • Treadmill stress test, Holter, Event and Loop monitors

Research profile

Mitchell Faddis Lab

Mitchell Faddis Lab

Research Interests:

    • Pathophysiology and treatment of atrial fibrillation
    • Development of new catheter based strategies for the treatment of atrial fibrillation

Clinical Interests:

    • Catheter ablation
    • Magnetic guidance
    • Congestive heart failure
    • Atrial fibrillation
    • Arrhythmias

Research profile

Michael J. Greenberg Lab

Michael J. Greenberg Lab

Research Interests:

    • Mechanobiology of cardiac contraction
    • Precision medicine for familial cardiomyopathies
    • Technology development

Lab website

Richard W. Gross Lab

Richard W. Gross Lab

Research Interests:

    • Chemical biology of membranes in health and disease

Research profile

Nathaniel Huebsch Lab

Nathaniel Huebsch Lab

Research Interests:

    • Pluripotent-stem cell derived cardiac micro-tissues for modeling cardiac development, drug toxicity and cardiomyopathy
    • Synthetic Extracellular Matrix Mimetics with defined presentation of adhesion ligands and growth factors

Lab website

R. Gilbert Jost Lab

R. Gilbert Jost Lab

Clinical Interests:

    • Radiology
    • Medical imaging
    • Digital radiology and networking
    • X-rays
    • Alternative screening

Profile

Sándor Kovács Lab

Sándor Kovács Lab

Research Interests:

    • Theoretical (mathematical) biology and physiology.
    • Characterization of physical properties of cardiovascular tissue
    • Maximal information extraction from in-vivo physiologic signals
    • Mathematical modeling of cardiovascular function
    • Nonlinear dynamics, thermodynamics and optimization principles of cardiovascular unction
    • Development of new technology for imaging and physiologic signal acquisition and processing

Lab website

Douglas Mann Lab

Douglas Mann Lab

Research Interests:

    • Innate immunity
    • Cardiac remodeling
    • Myocardial recovery

Lab website

Jonathan Moreno Lab

Jonathan Moreno Lab

Research Interests:

    • Multiscale computational models to understand mechanisms of arrhythmia in cardiomyopathy, heart failure, and inherited arrhythmia syndromes.
    • Hypertrophic cardiomyopathy
    • Computational cellular electrophysiology
    • 3D ventricular models
    • Drug repositioning strategies
    • Translational research on cardiac transplant and LVAD patients

Clinical Interests:

    • Advanced Heart Failure
    • Cardiac Transplantation
    • Cardiogenic shock, Mechanical Circulatory Support (LVADs)
    • Pulmonary Hypertension
    • Congestive Heart Failure
    • Myocardial Infarction
    • Diagnostic heart catheterization
    • Endomyocardial biopsy

Research profile

Arye Nehorai Lab

Arye Nehorai Lab

Research Interests:

    • Mathematical modeling of real-world systems
    • Statistical data analysis,
    • Signal processing
    • Machine learning for inference, prediction, decision making and optimal design for health, biomedicine and defense

Lab website

Jeanne Nerbonne Lab

Jeanne Nerbonne Lab

Research Interests:

    • Molecular, cellular and systemic mechanisms involved in the physiological regulation of cardiac and neuronal membrane excitability
    • How molecular, cellular and systemic mechanisms go awry in inherited and acquired disease
    • Impact of derangements in membrane excitability on cardiovascular and nervous system functioning

Lab website

Colin Nichols Lab

Colin Nichols Lab

Research Interests:

    • Lipid control of ion channel gating
    • Single molecule FRET
    • Vascular consequences of KATP gain-of-function
    • Cantu Syndrome – cardiac consequences of KATP gain-of-function
    • Modeling excitability-dependent diabetes in zebrafish
    • iPSC-derived cardiovascular tissues

Lab website

Joseph O’Sullivan Lab

Joseph O’Sullivan Lab

Research Interests:

    • Information theory
    • Information-theoretic imaging
    • Recognition theory and systems
    • CT imaging
    • Optical imaging
    • Information hiding
    • Hyperspectral imaging

Lab website

Maria S Remedi Lab

Maria S Remedi Lab

Research Interests:

    • Study in vivo physiology in various mouse models of diabetes to unravel the underlying mechanisms of pancreatic β-cell failure in glucotoxic stages, and their consequences in both pancreatic and extra-pancreatic tissues

Lab website

Stacey Rentschler Lab

Stacey Rentschler Lab

Research Interests:

    • Developmental Programming and Reprogramming of Conduction Tissue
    • Molecular Basis of Congenital Heart Defects

Lab website

Clifford Robinson Lab

Clifford Robinson Lab

Research Interests:

    • Lung cancer, esophageal cancer, and central nervous system malignancies
    • Stereotactic body radiation therapy (SBRT)
    • Spine radiosurgery, and Gamma Knife stereotactic radiosurgery

Clinical Interests:

    • Lung cancer, esophageal cancer
    • Brain tumor, spine tumor
    • Gamma Knife, stereotactic body radiation therapy (SBRT)

Research profile

Rajan Sah Lab

Rajan Sah Lab

Research Interests:

    • Ion channel signaling in the adipocyte
    • Ion channel regulation of pancreatic β-cell function
    • Modulators of calcium signaling in skeletal muscle
    • Novel ion channel signaling in myocardium
    • Ion channel signaling in endothelium

Research profile

Jingyi Shi Lab

Jingyi Shi Lab

Research Interests:

    • Molecular mechanisms of ion channel activation
    • Ion channels in association with diseases
    • Discovery of channel-modifying compounds

Lab website

Jennifer N. Avari Silva Lab

Jennifer N. Avari Silva Lab

Research Interests:

    • Clinical Applications of Noninvasive Electrocardiographic Imaging (ECGI)
    • Pediatric Cardiac Resynchronization Therapy

Clinical Interests:

    • Pediatric cardiology
    • Arrhythmia in children
    • Pediatric electrophysiology,

Research profile

Jonathan Silva Lab

Jonathan Silva Lab

Research Interests:

    • Linking Changes in Molecular Conformation to Cardiac Function
    • Spectroscopic Monitoring of Ion Channel Conformation
    • Cardiac Ion Channel and Action Potential Modeling

Lab website

Timothy W. Smith Lab

Timothy W. Smith Lab

Research Interests:

    • Cardiac cellular and tissue electrophysiology and mechanism of arrhythmias;
    • Treatment of arrhythmias, including pharmacologic therapy, ablation therapy, and implantable device therapy;
    • Device implantation techniques;
    • Prevention of sudden cardiac death

Clinical Interests:
Diagnostic electrophysiology, clinical arrhythmia, bradyarrhythmias, tachyarrthymia, atrial fibrillation, paroxysmal supraventricular tachycardias, ventricular arrhythmias, pacemaker implant, pacemaker evaluation, cardioverter defribrillators, catheter mapping, catheter ablation, risk assessment for sudden death, syncope (fainting), and palpitation

Research profile

Phyllis Stein Lab

Phyllis Stein Lab

Research Interests:

    • Risk stratification and mechanistic understanding of autonomic function from state of the art research analysis of continuous ECG monitoring-Holter, telemetry, polysomnography
    • Analysis of heart rate patterns to measure heart rate variability, identify normal and abnormal patterns, screen for sleep disorders also detect t-wave alternans

Lab website

Jason Trobaugh Lab

Jason Trobaugh Lab

Research Interests:

    • Probabilistic models for ultrasound images
    • Model-based image analysis
    • Treatment guidance applications for ultrasonic imaging
    • Clinical applications of inverse electrocardiography
    • Ultrasonic temperature imaging for management of thermal therapies

Research profile

George Van Hare Lab

George Van Hare Lab

Research Interests:

    • Multicenter clinical research in pediatric heart rhythm disorders; • Biology of atrioventricular node reentry;
    • Mapping and ablation of post-operative atrial and ventricular tachycardias

Clinical Interests:

    • Heart rhythm disorders in children, and in adults with congenital heart disease;
    • Radiofrequency catheter ablation, cryoablation, pacemaker, implantable cardioverter-defibrillator, (ICD), implantation and follow-up

Research profile

Pamela Woodard Lab

Pamela Woodard Lab

Research Interests:

    • Coronary MR angiography
    • Myocardial perfusion imaging
    • Coronary CT angiography
    • Atherosclerotic plaque characterization
    • Pulmonary embolism diagnosis and imaging biomarkers

Clinical Interests:

    • Cardiac CT and MRI
    • Pulmonary embolism diagnosis
    • Targeted molecular imaging

Research profile

Christian Zemlin Lab

Christian Zemlin Lab

Research Interests:

    • Atrial Fibrillation: Terminate with more precise lesions
    • Defibrillaton: Shorter shocks to avoid tissue damage
    • Heart attacks: Limit tissue loss with drugs that promote regeneration
    • Arrhythmia mechanisms: Studying the building blocks of arrhythmias
    • Realistic simulation of arrhythmia
    • Automated assessment of mouse sociability in behavioral movies

Research profile

Chao Zhou Lab

Chao Zhou Lab

Research Interests:

    • Space-division multiplexing optical coherence tomography (SDM-OCT)
    • Molecular-targeted OCT and OCM for cancer detection
    • OCT and OCM Imaging in Developmental Biology
    • 3D OCT imaging of Brain Functions
    • OCT (OCM) combined with deep learning
    • Optogenetic pacing in Drosophila melanogaster using integrated OCM imaging and red light stimulation system

Lab website