Jianmin Cui’s lab and collaborators study drug, electro-mechanical coupling link
Award supports continued research in seeking arrhythmia therapies
Imaging in Chao Zhou’s lab is promising method to study heart development, disease
Study suggests older drug may be safer for an advanced form of heart failure. Article features CBAC member Douglas L. Mann, the Tobias and Hortense Lewin Professor of Medicine.
Radiotherapy repairs irregular rhythms in those with life-threatening heart arrhythmia. New research from Washington University School of Medicine in St. Louis suggests that radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure.
Jonathan Silva and his lab use computational biology to better understand fundamentals of arrhythmia
CBAC member Nathaniel Huebsch receives nearly $2 million NIH grant to research the role that blood pressure plays in triggering symptoms in patients with hypertrophic cardiomyopathy.
Silva, Nerbonne labs investigate accessory proteins in steps toward precision medicine
CBAC Jianmin Cui leads a multi-institutional team to make this discovery. Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
CBAC Member Jonathan Moreno conducts cardiac research in Jon Silva’s lab in biomedical engineering.