Radiotherapy repairs irregular rhythms in those with life-threatening heart arrhythmia. New research from Washington University School of Medicine in St. Louis suggests that radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure.
Jonathan Silva and his lab use computational biology to better understand fundamentals of arrhythmia
CBAC member Nathaniel Huebsch receives nearly $2 million NIH grant to research the role that blood pressure plays in triggering symptoms in patients with hypertrophic cardiomyopathy.
Silva, Nerbonne labs investigate accessory proteins in steps toward precision medicine
CBAC Jianmin Cui leads a multi-institutional team to make this discovery. Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
CBAC Member Jonathan Moreno conducts cardiac research in Jon Silva’s lab in biomedical engineering.
Technology allows electrophysiologists to visualize cardiac anatomy in hands-free, real-time 3D. This article features CBAC members Jonathan Silva and Jennifer Silva.
Ghiska Ramahdita, a doctoral student in the labs of CBAC member Nathaniel Huebsch and Guy Genin, will continue on to compete in the finals May 4, 2021
New findings show how CaM and PIP2 orchestrate large-scale molecular movement of the KCNQ1 cytoplasmic domain to facilitate channel opening
Weikai Li, associate professor of biochemistry and molecular biophysics at the School of Medicine, along with CBAC Member Michael J. Greenberg, assistant professor of biochemistry and molecular biophysics, and Michael L. Gross, professor of chemistry in Arts & Sciences, and of immunology and of medicine at the School of Medicine, received a three-year $750,000 grant from American Heart Association for their research titled “Interdisciplinary structural studies of iron homeostasis in cardiovascular health.”