New findings show how CaM and PIP2 orchestrate large-scale molecular movement of the KCNQ1 cytoplasmic domain to facilitate channel opening
Weikai Li, associate professor of biochemistry and molecular biophysics at the School of Medicine, along with CBAC Member Michael J. Greenberg, assistant professor of biochemistry and molecular biophysics, and Michael L. Gross, professor of chemistry in Arts & Sciences, and of immunology and of medicine at the School of Medicine, received a three-year $750,000 grant from American Heart Association for their research titled “Interdisciplinary structural studies of iron homeostasis in cardiovascular health.”
A team led by Chao Zhou in biomedical engineering will use fruit flies to study a noninvasive stimulation and imaging technique to regulate an irregular heartbeat
With this funding, Zhou and his team plan to develop an ultrahigh-speed parallel imaging optical coherence tomography (OCT) system for motion-free imaging in children
Richard Schuessler, PhD, Director of the Cardiac Surgical Research Laboratory, retires from the Department of Surgery in October 2020, after an accomplished 35-year career at Washington University School of Medicine in St. Louis.
CBAC Members, Jennifer and Jon Silva have developed a hologram that visualises a patient’s heart while they are in the operating theatre. They were featured on BBC News. Click on the title or image for their BBC News video.
Holographic display improves physician accuracy when treating irregular heartbeat. CBAC members, Jennifer N. Avari Silva, MD, associate professor of pediatrics at the School of Medicine, and Jonathan Silva, associate professor of biomedical engineering in the McKelvey School of Engineering, co-led a team that tested a Microsoft HoloLens headset with custom software during cardiac ablation procedures on patients at St. Louis Children’s Hospital.
CBAC members, Jon Silva’s and Jeanne Nerbonne’s lab will investigate a novel protein component of the cardiac sodium channels to determine its functional effects in the physiological regulation and pathophysiological remodeling of electrical propagation of the heart.
Rudy lab conducts first study of electromechanics of healthy, living human hearts. While there have been numerous studies of abnormalities in the human heart, there have not been studies of the electromechanics of healthy adult hearts — until now.
Chancellor Martin announced that CBAC Director and Fred Saigh Distinguished Professor of Engineering, Yoram Rudy has received the Chancellor’s Award for Innovation and Entrepreneurship. Rudy gave a presentation on his work during the award ceremony on November 8.