New findings show how CaM and PIP2 orchestrate large-scale molecular movement of the KCNQ1 cytoplasmic domain to facilitate channel opening
A team led by Chao Zhou in biomedical engineering will use fruit flies to study a noninvasive stimulation and imaging technique to regulate an irregular heartbeat
CBAC Members, Jennifer and Jon Silva have developed a hologram that visualises a patient’s heart while they are in the operating theatre. They were featured on BBC News. Click on the title or image for their BBC News video.
Holographic display improves physician accuracy when treating irregular heartbeat. CBAC members, Jennifer N. Avari Silva, MD, associate professor of pediatrics at the School of Medicine, and Jonathan Silva, associate professor of biomedical engineering in the McKelvey School of Engineering, co-led a team that tested a Microsoft HoloLens headset with custom software during cardiac ablation procedures on patients at St. Louis Children’s Hospital.
CBAC members, Jon Silva’s and Jeanne Nerbonne’s lab will investigate a novel protein component of the cardiac sodium channels to determine its functional effects in the physiological regulation and pathophysiological remodeling of electrical propagation of the heart.
Rudy lab conducts first study of electromechanics of healthy, living human hearts. While there have been numerous studies of abnormalities in the human heart, there have not been studies of the electromechanics of healthy adult hearts — until now.
Patients with irregular heartbeats, or arrhythmia, have few effective treatment options — available drugs are not always effective, and implanted defibrillators can be too aggressive.
This article features the work of CBAC member Jonathan Silva, PhD, Associate Professor of Biomedical Engineering.
A single high dose of radiation aimed at the heart significantly reduces episodes of a potentially deadly rapid heart rhythm, according to results of a phase one/two study at Washington University School of Medicine in St. Louis. This article features the work of CBAC members Clifford G. Robinson, MD, an associate Professor of radiation oncology and of cardiology, and Phillip S. Cuculich, MD, an associate Professor of Cardiology and of radiation oncology.
CBAC member Jennifer Silva, MD, a pediatric electrophysiologist at Washington University School of Medicine in St. Louis, treats children with abnormal heart rhythms. She has co-founded a startup company that is developing technology intended to help doctors see real-time 3D holograms of the heart during procedures to fix erratic heart rhythms.
Two graduate students turned entrepreneurs transformed a medical breakthrough from a lab project into a clinical tool. Years later, Medtronic bought the company they co-founded for $93 million.
After new technology recently revealed the structure of the protein, the lab of CBAC member Jianmin Cui, professor of biomedical engineering in the School of Engineering & Applied Science, will collaborate with two others to take an unprecedented look into its molecular mechanisms potentially leading to the development of new drugs for these and other conditions.
Physicians and patients have long awaited the next step beyond catheter ablation for ventricular tachycardia (VT). Could noninvasive stereotactic body radiation be that breakthrough?
Scientists studying link between rare disease and heart health
CBAC member, Colin Nichols, the Carl F. Cori Professor of Cell Biology and Physiology, has received a grant to study how the genetic mutations underlying Cantu syndrome are linked to cardiovascular disease.
Pediatric cardiologist seeks keys to preventing congenital heart defects.
This article features CBAC alumnus Patrick Jay, who was an associate professor of pediatrics at Washington University School of Medicine in St. Louis.
Engineers find unexpected results during cardiac research. This article features CBAC members Jonathan Silva, assistant professor of biomedical engineering, and Jeanne Nerbonne, Alumni Endowed Professor of Molecular Biology and Pharmacology and director of the Center for Cardiovascular Research at Washington University’s School of Medicine.
Silva, Nerbonne and Zoltan Varga from the University of Debrecen in Hungary worked with collaborators to take a closer look at the sodium ion channels responsible for creating the electrical signal that makes the heartbeat.They found that certain sodium subunits attached to the main protein in different places. It was an unexpected result that could lead to better drug delivery and efficacy for patients with heart arrhythmia.
CBAC member Jianmin Cui, professor of biomedical engineering, and collaborators in three labs at WashU are studying the BK channel, which has been found to be important in regulating neuronal function and blood pressure.
Jon Silva and his team will study how small molecules and proteins interact with ion channels in the heart to cause and prevent arrhythmia, when the heart beats too fast, too slow, or is too unstable
The CardioInsight ECGI system was cleared by the FDA. After 30 years of development and validation in CBAC Director Yoram Rudy’s laboratory, he hopes to see ECGI in clinical use in hospitals, helping to treat cardiac patients.
CBAC member George F. Van Hare III, MD, director of the Division of Pediatric Cardiology at Washington University School of Medicine in St. Louis, has been named president-elect of the Heart Rhythm Society, a global research and education group focused on cardiac rhythm disorders.
CBAC member Arye Nehorai, the Eugene and Martha Lohman Professor of Electrical Engineering and chair of the Department of Electrical & Systems Engineering in the School of Engineering & Applied Science, and his team have developed the first 3-D multiscale mathematical model of the electrophysiology of a woman’s contractions as they begin from a single cell to the myometrium, or uterine tissue, into the uterus
While working a Case Western Reserve University, CBAC Director Yoram Rudy, PhD had the idea for a game-changing cardiac monitoring device–a vest filled with more than 200 sensors that could detect the heart’s electrical activity. While standard 12-lead EKGs had become the gold standard for detecting many heart problems, EKGs still can miss cardiac problems because they only probe electrical potential at a limited number of points on the body.
Medtronic acquired CardioInsight Technologies, developer of a clinical noninvasive imaging system, called ECGI, for noninvasive mapping of the electrical activity of the heart and cardiac arrhythmias. The ECGI concept and methodology were developed in Professor Yoram Rudy’s laboratory with support from the NIH – National Heart, Lung and Blood Institute.
Findings could lead to better treatment for cardiac arrhythmia and long QT syndrome.CBAC member Jianmin Cui, PhD, has received a nearly $1.7 million grant from the National Institutes of Health (NIH) to study the molecular bases for the function of potassium channels vital for the heart, brain, inner ear and other tissues.
CBAC member Pamela Woodard, MD, led a team that designed a new imaging agent that may light up dangerous plaque in arteries.
CBAC alumnus Lihong Wang, the Gene K. Beare Professor of Biomedical Engineering, continues to build on his groundbreaking technology that allows light deep inside living tissue during imaging and therapy.
CBAC members Jianmin Cui, PhD, professor of biomedical engineering, and Mark Zaydman, fifth-year MD/PhD student, and a team of biomedical engineers has discovered that for one important channel in the heart, called KCNQ1, the membrane voltage not only causes the channel to open, but also determines the properties of the electrical signals, acting as both conductor and composer rather than only conductor as previously believed.
Injecting beads of gel into the wall of a still-beating heart has the potential to improve the health of patients with severe heart failure, according to a new study by CBAC member Douglas L. Mann, MD, the Tobias and Hortense Lewin Professor of Medicine and cardiologist-in-chief at Barnes-Jewish Hospital. Mann presented the study’s findings at the American Heart Association (AHA) annual meeting in Chicago.